USE OF THE COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL FOR TREATING HER2-POSITIVE TUMORS EXPERIMENTALLY
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology. Disclosed is use of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol for treating HER2-positive tumors experimentally in dose of 15-20 mg/kg parenterally.EFFECT: in mice FVB/N with spontaneous or transplantable HER2-p...
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| creator | Vasileva Olesya Aleksandrovna Egormin Petr Andreevich Filatova Larisa Valentinovna Senchik Konstantin Yurevich Stukov Aleksandr Nikolaevich Bakhidze Elena Villevna Tochilnikov Grigorij Viktorovich Yurova Mariya Nikolaevna Semiglazova Tatyana Yurevna Bespalov Vladimir Grigorevich Majdin Mikhail Aleksandrovich Konstantinov Leonid Vladimirovich Panchenko Andrej Vladimirovich Plakhov Evgenij Aleksandrovich Tyndyk Margarita Leonidovna Poltoratskij Artem Nikolaevich Semenov Aleksandr Leonidovich Ivantsov Aleksandr Olegovich Vershinina Sofiya Fatkhutdinovna Latipova Dilorom Khamidovna Anisimov Vladimir Nikolaevich Chubenko Vyacheslav Andreevich Kozyavin Nikita Aleksandrovich Kireeva Galina Sergeevna |
| description | FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology. Disclosed is use of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol for treating HER2-positive tumors experimentally in dose of 15-20 mg/kg parenterally.EFFECT: in mice FVB/N with spontaneous or transplantable HER2-positive breast cancer 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (intraperitoneally) once caused partial and even complete temporary regression of tumor; invention extends the range of products for treating HER2-positive tumors, increases the therapeutic effect in suppressing tumor growth.1 cl, 2 dwg, 6 tbl, 3 ex
Изобретение относится к медицине, а именно к онкологии. Предложено применение 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиола для лечения HER2-положительных опухолей в эксперименте в дозе 15-20 мг/кг парентерально. Технический результат: у мышей FVB/N со спонтанным или перевиваемым HER2-положительным раком молочной железы 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиол (внутрибрюшинно) однократно вызывал частичную и даже полную временную регрессию опухоли. Изобретение расширяет арсенал средств лечения HER2-положительных опухолей, повышает терапевтический эффект в подавлении роста опухоли. 2 ил., 6 табл., 3 пр. |
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Изобретение относится к медицине, а именно к онкологии. Предложено применение 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиола для лечения HER2-положительных опухолей в эксперименте в дозе 15-20 мг/кг парентерально. Технический результат: у мышей FVB/N со спонтанным или перевиваемым HER2-положительным раком молочной железы 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиол (внутрибрюшинно) однократно вызывал частичную и даже полную временную регрессию опухоли. Изобретение расширяет арсенал средств лечения HER2-положительных опухолей, повышает терапевтический эффект в подавлении роста опухоли. 2 ил., 6 табл., 3 пр.</description><language>eng ; rus</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190726&DB=EPODOC&CC=RU&NR=2695787C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190726&DB=EPODOC&CC=RU&NR=2695787C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Vasileva Olesya Aleksandrovna</creatorcontrib><creatorcontrib>Egormin Petr Andreevich</creatorcontrib><creatorcontrib>Filatova Larisa Valentinovna</creatorcontrib><creatorcontrib>Senchik Konstantin Yurevich</creatorcontrib><creatorcontrib>Stukov Aleksandr Nikolaevich</creatorcontrib><creatorcontrib>Bakhidze Elena Villevna</creatorcontrib><creatorcontrib>Tochilnikov Grigorij Viktorovich</creatorcontrib><creatorcontrib>Yurova Mariya Nikolaevna</creatorcontrib><creatorcontrib>Semiglazova Tatyana Yurevna</creatorcontrib><creatorcontrib>Bespalov Vladimir Grigorevich</creatorcontrib><creatorcontrib>Majdin Mikhail Aleksandrovich</creatorcontrib><creatorcontrib>Konstantinov Leonid Vladimirovich</creatorcontrib><creatorcontrib>Panchenko Andrej Vladimirovich</creatorcontrib><creatorcontrib>Plakhov Evgenij Aleksandrovich</creatorcontrib><creatorcontrib>Tyndyk Margarita Leonidovna</creatorcontrib><creatorcontrib>Poltoratskij Artem Nikolaevich</creatorcontrib><creatorcontrib>Semenov Aleksandr Leonidovich</creatorcontrib><creatorcontrib>Ivantsov Aleksandr Olegovich</creatorcontrib><creatorcontrib>Vershinina Sofiya Fatkhutdinovna</creatorcontrib><creatorcontrib>Latipova Dilorom Khamidovna</creatorcontrib><creatorcontrib>Anisimov Vladimir Nikolaevich</creatorcontrib><creatorcontrib>Chubenko Vyacheslav Andreevich</creatorcontrib><creatorcontrib>Kozyavin Nikita Aleksandrovich</creatorcontrib><creatorcontrib>Kireeva Galina Sergeevna</creatorcontrib><title>USE OF THE COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL FOR TREATING HER2-POSITIVE TUMORS EXPERIMENTALLY</title><description>FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology. Disclosed is use of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol for treating HER2-positive tumors experimentally in dose of 15-20 mg/kg parenterally.EFFECT: in mice FVB/N with spontaneous or transplantable HER2-positive breast cancer 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (intraperitoneally) once caused partial and even complete temporary regression of tumor; invention extends the range of products for treating HER2-positive tumors, increases the therapeutic effect in suppressing tumor growth.1 cl, 2 dwg, 6 tbl, 3 ex
Изобретение относится к медицине, а именно к онкологии. Предложено применение 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиола для лечения HER2-положительных опухолей в эксперименте в дозе 15-20 мг/кг парентерально. Технический результат: у мышей FVB/N со спонтанным или перевиваемым HER2-положительным раком молочной железы 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиол (внутрибрюшинно) однократно вызывал частичную и даже полную временную регрессию опухоли. Изобретение расширяет арсенал средств лечения HER2-положительных опухолей, повышает терапевтический эффект в подавлении роста опухоли. 2 ил., 6 табл., 3 пр.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyr0KwjAQAOAuDqK-w40K3mCLf2NpryaQ5sL1IoqIiMRJVNDJp3fxAZy-5etnn9gRcANqCCpuA0dfQ46HAsc5VsaxMKnZuwkW6K0KdxyFbM1HnE0LDMKh9FRbdtCwgAqVav0GDEmOgTurdkugsWXpgHaBxLbktXRuP8x61_PtlUY_Bxk0pJXB9Hyc0ut5vqR7ep8k5ov1fLlaVrPij_IFbJc6Yg</recordid><startdate>20190726</startdate><enddate>20190726</enddate><creator>Vasileva Olesya Aleksandrovna</creator><creator>Egormin Petr Andreevich</creator><creator>Filatova Larisa Valentinovna</creator><creator>Senchik Konstantin Yurevich</creator><creator>Stukov Aleksandr Nikolaevich</creator><creator>Bakhidze Elena Villevna</creator><creator>Tochilnikov Grigorij Viktorovich</creator><creator>Yurova Mariya Nikolaevna</creator><creator>Semiglazova Tatyana Yurevna</creator><creator>Bespalov Vladimir Grigorevich</creator><creator>Majdin Mikhail Aleksandrovich</creator><creator>Konstantinov Leonid Vladimirovich</creator><creator>Panchenko Andrej Vladimirovich</creator><creator>Plakhov Evgenij Aleksandrovich</creator><creator>Tyndyk Margarita Leonidovna</creator><creator>Poltoratskij Artem Nikolaevich</creator><creator>Semenov Aleksandr Leonidovich</creator><creator>Ivantsov Aleksandr Olegovich</creator><creator>Vershinina Sofiya Fatkhutdinovna</creator><creator>Latipova Dilorom Khamidovna</creator><creator>Anisimov Vladimir Nikolaevich</creator><creator>Chubenko Vyacheslav Andreevich</creator><creator>Kozyavin Nikita Aleksandrovich</creator><creator>Kireeva Galina Sergeevna</creator><scope>EVB</scope></search><sort><creationdate>20190726</creationdate><title>USE OF THE COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL FOR TREATING HER2-POSITIVE TUMORS EXPERIMENTALLY</title><author>Vasileva Olesya Aleksandrovna ; 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Disclosed is use of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol for treating HER2-positive tumors experimentally in dose of 15-20 mg/kg parenterally.EFFECT: in mice FVB/N with spontaneous or transplantable HER2-positive breast cancer 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (intraperitoneally) once caused partial and even complete temporary regression of tumor; invention extends the range of products for treating HER2-positive tumors, increases the therapeutic effect in suppressing tumor growth.1 cl, 2 dwg, 6 tbl, 3 ex
Изобретение относится к медицине, а именно к онкологии. Предложено применение 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиола для лечения HER2-положительных опухолей в эксперименте в дозе 15-20 мг/кг парентерально. Технический результат: у мышей FVB/N со спонтанным или перевиваемым HER2-положительным раком молочной железы 2-[3-(2-хлорэтил)-3-нитрозоуреидо]-1,3-пропандиол (внутрибрюшинно) однократно вызывал частичную и даже полную временную регрессию опухоли. Изобретение расширяет арсенал средств лечения HER2-положительных опухолей, повышает терапевтический эффект в подавлении роста опухоли. 2 ил., 6 табл., 3 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| title | USE OF THE COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL FOR TREATING HER2-POSITIVE TUMORS EXPERIMENTALLY |
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