DERIVATIVE BASED ON DIHYDROPYRIMIDO-RING AS HBV INHIBITOR

FIELD: chemistry.SUBSTANCE: invention relates to a novel dihydropyrimidinium compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I)(I)0-2 of D-separately and independently selected from a single bond, -C(=O)N(R)-, -N(R)-, -S(=O)N(R) -, -S(=O)N(R)-, -O-, -S-, -C(=O)O-, -C(=O) - or -S(=O)-, and the rest are selected from -C(R)(R)-; L is selected from a single bond, -S-, -NH-, -S(=O)-, -S(=O)-, -N(R)-, -[C(R)(R(I)]; Ris selected from;Dis selected from a single bond, -N(R)-, -O-, where Rdis hydrogen; Ris independently selected from H, Calkyl, which is optionally substituted with R, wherein each of Ris independently selected from F, Cl, Br, I, Calkyl; Rseparately and independently selected from following groups, optionally substituted with R:6-10-membered aromatic ring group or 5-6-member heteroaromatic ring group containing a sulphur atom or a nitrogen atom as a heteroatom, wherein each of Ris independently selected from F, Cl, Br, I, C-alkyl; Rseparately and independently selected from following groups, optionally substituted with R: C-alkyl or 5-6-member heteroaromatic ring group containing nitrogen and sulphur atoms or a nitrogen atom as a heteroatom, wherein each of Ris independently selected from F, Cl, Br, I, Calkyl; Ris selected from H, Calkyl; Rand R-separately and independently selected from H, CN, Calkyl, benzyl optionally substituted with Calkoxy; Ris selected from H, Calkyl, CN, or selected from the following groups, optionally substituted with R: -C(=O)O-C-alkyl, -S(=O)NH-C-alkyl, -C(=O)-C-alkyl, -S(=O)-C-alkyl, -C(=O)NH-C-alkyl, 3-6-member heterocyclylcarbonyl, where heterocyclyl has oxygen as a heteroatom, -C(=O)-C-cycloalkyl, C-alkyl-5-6-member heteroaryl with 1-2 heteroatoms selected from nitrogen or oxygen or nitrogen and oxygen, -S(=O)-C-cycloalkyl, -C-alkyl-C(=O)NH, -C-alkylphenyl, -C-alkyl-C(=O)O-C-alkyl, -C-alkyl-C(=O)OH, 3-6-member heterocyclyl with oxygen as a heteroatom and -C(=S)NH-C-alkyl, wherein Ris independently selected from NH, C-alkyl, C-alkoxy; R-separately and independently selected from H, CN, OH, NH, COOH, or selected from the following optionally substituted with Rgroups: C-alkyl, C-alkylphenyl, C-alkyl-3-6-member heterocyclyl with 1-4 heteroatoms selected from nitrogen or oxygen or nitrogen and oxygen, 3-6-member heterocyclylcarbonyl, where heterocyclyl has 1-4 heteroatoms selected from nitrogen or oxygen, or nitrogen and oxygen, or a nitrogen atom and sulfur or sulphoxide thereof, benzenesu