SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS

SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS

FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and notably to specific imidazo[4,5-c]pyridine derivatives. Invention also relates to a pharmaceutical composition based on a specific imidazo[4,5-c]pyridine derivative useful in treating cancer.EFFECT: technical result is obtaining...

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Hauptverfasser: SAMALA Dzhajya Prakash, KAMMARANO Karolin Mishel, ROJTERSHAN Majkl Khejl, DOLL Ronald Dzh, PANDA Dzhagannatkh, YAN Lipin, BODZHEN Stefan L, TROTTER B. Uesli, GKHOSH Partkha, BOLISETTI Ragkhu, VOSS Mettyu E, FRADERA LINAS Fransesk Ksaver, ALTMAN Majkl D, TOMPSON Kristofer Frensis, MARTINES Mishel, MASHASEK Mishell, KRISTOFER Mettyu P, SUN Binyuan, SIDZUKA Manami, TONI KURISSERI Antkhappan
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and notably to specific imidazo[4,5-c]pyridine derivatives. Invention also relates to a pharmaceutical composition based on a specific imidazo[4,5-c]pyridine derivative useful in treating cancer.EFFECT: technical result is obtaining novel imidazopyridine derivatives useful as HDM2 protein inhibitors.17 cl, 1 dwg, 21 tbl, 360 ex Изобретение относится к области органической химии, а именно к конкретным производным имидазо[4,5-c]пиридина. Также изобретение относится к фармацевтической композиции на основе конкретного производного имидазо[4,5-c]пиридина, полезной для лечения рака. Технический результат: получены новые производные имидазопиридина, полезные в качестве ингибиторов HDM2 белка. 6 н. и 11 з.п. ф-лы, 1 ил., 21 табл., 360 пр.