METHODS OF COMBINED THERAPY USING BINDING MATERIALS WITH PSL AND PCRV PSEUDOMONAS

FIELD: immunology.SUBSTANCE: present invention relates to immunology. Disclosed an antibody and its antigen-binding fragment, which specifically bind to PcrV, as well as a bispecific antibody containing a domain, which binds Psl, and a domain which binds to PcrVInvention also describes: a polynucleo...

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Hauptverfasser:	CHOVDKHURI Partkha, REJNI Godfri, UORRENER Pol, TOMICH Mladen, DIMASI Natstsareno, RAST Stiven, DAMSHRODER Melissa, GAO Tsujkhua, DIDZHANDOMENIKO Antonio, GILLARD Sandrin, PENG Li, FLEMING Rajan, BEZABEKH Biniam, VARKI Rina, STOUVER Charlz, VENKATRAMAN Vignesh, GAO Chanshou, SELLMAN Bret, MINTER Ralf
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: immunology.SUBSTANCE: present invention relates to immunology. Disclosed an antibody and its antigen-binding fragment, which specifically bind to PcrV, as well as a bispecific antibody containing a domain, which binds Psl, and a domain which binds to PcrVInvention also describes: a polynucleotide molecule coding the antibody according to the invention; composition containing the disclosed antibody, and a method for preventing or treating an infection caused by.EFFECT: present invention can find further application in therapy.15 cl, 35 dwg, 20 ex, 7 tbl Настоящее изобретение относится к иммунологии. Предложено антитело и его антигенсвязывающий фрагмент, которые специфически связываются с PcrV, а также биспецифическое антитело, содержащее домен, который связывается с Psl, и домен, который связывается с PcrV. Кроме того, описаны: молекула полинуклеотида, кодирующая антитело по изобретению; композиция, содержащая антитело по изобретению, и способ профилактики или лечения инфекции, вызванной. Данное изобретение может найти применение в терапии. 5 н. и 10 з.п. ф-лы, 35 ил., 7 табл., 20 пр.