PHARMACEUTICAL FORMULATIONS OF HIF HYDROXYLASE INHIBITORS

FIELD: pharmaceuticals.SUBSTANCE: group of inventions relates to the pharmaceutical industry and is a pharmaceutical formulation for treatment, pretreatment or delay in the onset or progression of conditions associated with anemia, ischemia, or hypoxia, containing [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]acetic acid, an adjuvant, a photo stabilizing agent that prevents the passage of light in the wavelength range from 200 nm to 550 nm, the specified photo stabilizing agent contains titanium dioxide and an additional dye. Inventions also include a solid dosage form containing said pharmaceutical formulation, which is a tablet, and also a solid dosage form, containing said pharmaceutical formulation, which is a capsule. Invention presents a method of inhibiting photodegradation of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, which includes the preparation of the [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid formulation with an effective amount of a photo stabilizing agent, which contains titanium dioxide and at least one additional dye, a method of treatment, pretreatment or delay in the onset or progression of a condition mediated at least in part by a hypoxia induced factor (HIF), including the administration to a patient in need of a specified pharmaceutical formulation or said solid dosage forms, as well as a method for treatment, pretreatment, or delay of the onset or progression of anemia, including administering to a patient in need thereof said pharmaceutical formulation or said solid dosage forms.EFFECT: group of inventions provides increased photostability of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid.27 cl, 4 dwg, 8 tbl, 3 ex Группа изобретений относится к химико-фармацевтической промышленности и представляет собой фармацевтический состав для лечения, предварительного лечения или задержки возникновения или прогрессирования состояний, связанных с анемией, ишемией или гипоксией, содержащий [(4-гидрокси-1-метил-7-феноксиизохинолин-3-карбонил)-амино]-уксусную кислоту, вспомогательное вещество, фотостабилизирующий агент, который препятствует прохождению света в диапазоне длин волн от 200 нм до 550 нм, указанный фотостабилизирующий агент содержит диоксид титана и дополнительный краситель. Также изобретения включают твёрдую лекарственную форму, содержащую указанный фармацевтический состав, представляющую собой таблетку, а также твёрдую лекарст