SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

FIELD: chemistry.SUBSTANCE: invention relates to 2-aminopyridine derivatives of Formula (I) and Formula (III)(I)(III), where Ais selected from the group consisting of a hydrogen atom and -O-(CHR)-A; Ris selected unsubstituted methyl and methyl having 1-3 halogen atoms as substituents; Ais phenyl optionally having one or more Ras substituents; Ris selected from the group consisting of a halogen atom, an unsubstituted Calkyl and Calkyl substituted with halogen atom (s); Ais selected from the group consisting of phenyl, pyridinyl and pyrimidinyl, optionally substituted with one or more substituents selected from halo and -OCalkyl, in which each hydrogen atom Calkyl moiety is optionally substituted with hydroxy or heteroalicyclic; Ais a heteroalicyclyl which optionally has one or more substituents selected from the group consisting of =O, unsubstituted Calkyl, heteroalicyclyl, wherein heteroalicyclyl is optionally further substituted with a substituent(s) selected from the group consisting of Calkyl, =O, -OH, -COOH, -CN, a halogen atom, -NH(Calkyl) and -N(Calkyl), and Calkyl substituted with heteroalicyclic; Ais selected from the group consisting of a hydrogen atom, a heteroaryl having as a substituent a phenyl, and heteroaryl ethynyl having as a substituent heteroarylalkyl, wherein each phenyl and heteroaryl optionally have one or more substituents selected from the group consisting of a halogen atom, Calkyl optionally having a halogen atom as substituents; provided that Aand AAt the same time they are not hydrogen atoms and one of Aand Amust be a hydrogen atom; and when Ais -O-(CHR)-Aand Ris methyl, Ahas, as substituents, at least one -OCalkyl, where Cthe alkyl moiety is optionally substituted with hydrogen or heteroalicyclic; and pharmaceutically acceptable salts thereof having an inhibitory activity against protein kinase.EFFECT: substituted 2-aminopyridine protein kinase inhibitor.32 cl, 5 tbl, 56 ex Изобретение относится к производным 2-аминопиридина Формулы (I) и Формулы (III)где Aвыбран из группы, состоящей из атома водорода и -O-(CHR)-A; Rвыбран из группы, состоящей из незамещенного метила и метила, имеющего в качестве заместителей 1-3 атома галогена; Апредставляет собой фенил, необязательно имеющий в качестве заместителей один или более чем один R; Rвыбран из группы, состоящей из атома галогена, незамещенного Cалкила и Салкила, замещенного атомом(ами) галогена; Aвыбран из группы, состоящей из фенила, пиридинила и пиримидинила, все из которых необязат