SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS

FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, namely to a heterocyclic compound of formula (I), where Z - CH or N; I) wherein, when Z is CH, then Ris selected from -H and -Calkyl; Y is -C (R)-, wherein each Ris independently selected from -H, -F, -CH, -OH and -N(R); Ris selected from A) phenyl, unsubstituted or substituted with one substituent R, wherein Ris selected from halogen, -CN, -COR, -CONH, -SOCH, -C(R)OH, -CHNH, -CHCONH, -CHCOCalkyl, -NHCONH, -NHCONH-oxetane, -CONH-oxetane,and; B) six-membered monocyclic heteroaromatic ring containing one or two nitrogen atoms, unsubstituted or substituted with one or two substituents each independently selected from halogen, -Calkyl, -Chaloalkyl, -CN, -OH, -C(R)OH, -CHNH, -C(R)CN, -C(R)CONH, -OCHCONH, -OCalkyl, -OCHC(R)OH, -OCHcyclopropyl, -OChaloalkyl, -COH, -CON(R), -N(R), -NHCHCF, -NHCH(CH), -NHCHCHN(CH), -NHCHCHOH, -NH-cyclopropyl, -NHCOCH, morpholinyl, pyrrolidin-3-ol and azetidin-3-ol; C) five-membered monocyclic heteroaromatic ring containing two, three or four nitrogen atoms, unsubstituted or substituted with one or two substituents each independently selected from halogen,-Calkyl, -Chaloalkyl, -C(R)OH, -N(R), -NO, -CN, -CHCN, -OCalkyl, -CHOCH, -CHCHOH, -CHNH, -CHCONH, -COCalkyl, -COH, -CONH, -NHCOCHand cyclopropyl; and D) five- or six-membered ring selected from: 1,2-dihydropyridin-2-one, thiazole or 1,2-oxazole, unsubstituted or substituted with one or two substituents each independently selected from -CHand -NH; Ris phenyl or pyridine, each of which is substituted with one or two substituents each independently selected from -halogen, -Calkyl, -OCalkyl, -O-cyclopropyl, -O-oxetane, -Chaloalkyl, -COgaloalkyl, -CN, -CHOH, -SOCHand -N(CH); Ris selected from -Calkyl and -Chaloalkyl; and each Ris -H or -CH; II) wherein, when Z is N, then Ris H; Y is -CH-; Ris selected from A) phenyl substituted with one substituent R, wherein Ris selected from -CN, -CONHand -COCalkyl; B) six-membered monocyclic heteroaromatic ring containing one or two nitrogen atoms unsubstituted or substituted with a substituent selected from -CN, -OCalkyl, -CONH, -NHCHCHOH, -N(R)and -NH-cyclopropyl; C) five-membered monocyclic heteroaromatic ring containing two or three nitrogen atoms, unsubstituted or substituted with one or two substituents, each selected from -Calkyl, -Chaloalkyl, -CHOR, -N(R), -NO, -COCH, -CON(R)and cyclopropyl; and D) 1,2-oxazole optionally substituted with one or two R; Ris phenyl substituted w