TRK-INHIBITING COMPOUND

FIELD: medicine.SUBSTANCE: invention relates to a compound of general formula (I) wherein the Cycycle is phenyl, cyclohexyl, pyridinyl, pyrazolyl, triazolyl, thienyl, tetrahydrofuranyl; Cycycle is a pyridine ring, a pyrimidine ring, a pyrazolopyrimidine ring, an imidazopyridine ring, an imidazopyrid...

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Hauptverfasser: NAGAURA Takesi, KHASIMURA Kazuya, IKURA Masakhiro, YASUKHIRO Tetsuya, ITADANI Satosi, TAKEUTI Dzun, KHIGASINO Masato
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: medicine.SUBSTANCE: invention relates to a compound of general formula (I) wherein the Cycycle is phenyl, cyclohexyl, pyridinyl, pyrazolyl, triazolyl, thienyl, tetrahydrofuranyl; Cycycle is a pyridine ring, a pyrimidine ring, a pyrazolopyrimidine ring, an imidazopyridine ring, an imidazopyridine ring, a pyrrolopyridine ring, an imidazopyrazine ring or a pyrazolopyridine ring; Rrepresents a halogen; C-alkyl group optionally substituted with 1 to 3 substituents selected from the group consisting of (i) halogen and (ii) hydroxy or Calkynyl group; phenyl optionally substituted with one or two Rgroups or indanyl; A 5-6 membered monocyclic heterocycle optionally substituted with one or two Rgroups or dihydrobenzofuran; -S(O)-R; -SONRR; -OR; Rrepresents a halogen; cyano group; or C-alkyl group optionally substituted with 1 to 3 substituents selected from the group consisting of (i) halogen, (ii) hydroxy groups and (iii) oxo groups; when there are two groups R, the group Rindependently may be the same or different; R, R, R, Ror Rrespectively and independently represent (1) a hydrogen atom or (2) Calkyl group optionally substituted by (ii) a hydroxy group; Rrepresents a halogen; C-alkyl group optionally substituted with (i) a halogen or (ii) a hydroxy group; C-cycloalkyl group; C-alkoxy group; -NRR; pyrrolidinyl, azetidinyl; or -O-(oxetanyl); Rand Rrespectively and independently represent a hydrogen atom or Calkyl group optionally substituted by (ii) a hydroxy group; Aand Arespectively and are independently =CR- or =N-; A, A, Aand Arespectively and are independently =CR-; Rand Rrespectively and independently represent a hydrogen atom; m1 is an integer from 0 to 2; p is an integer from 0 to 4; q is an integer from 0 to 2; r represents 0; provided that when p, q and r are respectively an integer of 2 or more, group R, Rand Rrespectively, and independently may be the same or different, or a pharmaceutically acceptable salt thereof. Invention also relates to a pharmaceutical composition having an inhibitory activity against Trk based on a compound of formula (I).(I).EFFECT: technical result consists in that new compounds have been obtained that can be used in medicine for the treatment of pain or cancer.18 cl, 8 tbl, 23 ex Изобретение относится к соединению общей формулы (I), в которой цикл Cyпредставляет собой фенил, циклогексил, пиридинил, пиразолил, триазолил, тиенил, тетрагидрофуранил; цикл Cyпредставляет собой пиридиновый цикл, пиримидиновый цикл, пиразолоп