NOVEL COMPOUNDS THAT ARE ERK INHIBITORS

NOVEL COMPOUNDS THAT ARE ERK INHIBITORS

FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula (1) in which the radicals and symbols have the meanings indicated in the claims and to pharmaceutically acceptable salts thereof. Compounds of formula (1) are ERK inhibitors..EFFECT: invention also relates to a pharmaceutical comp...

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Hauptverfasser: FEVRIER Salem, KOZLOVSKI Dzhozef, LIPFORD Ketrin, MALETIK Milana M, CHEN Lej, METOT Dzhoi L, MANSUR Umar Faruk, BAKSHI Raman Kumar, SHINKRE Bidkhan A, LIM Chzhongvon, TUN Lin, UILSON Kevin Dzh, KARUNAKARAN Ganesh Babu, O'BOJL Brendan, SILIPKHAIVANKH Pkhieng, BOJS Kristofer, DENIELS Mettyu KH, KHUAN Syankhaj, SLOMAN Devid, TKHATAJ Dzhayantkh Tkhiruvellore, FALKONE Deniell, KURUKULASURIYA Ravi, UITTER Devid Dzh, CHZHOU Vej
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula (1) in which the radicals and symbols have the meanings indicated in the claims and to pharmaceutically acceptable salts thereof. Compounds of formula (1) are ERK inhibitors..EFFECT: invention also relates to a pharmaceutical composition comprising and to methods for treating malignant neoplasms using a compound of formula (1).16 cl, 6 tbl, 458 ex Изобретение относится к соединениям формулы (1), в которой радикалы и символы имеют значения, указанные в формуле изобретения, и к их фармацевтически приемлемым солям. Соединения формулы (1) являются ингибиторами ERK. Изобретение также относится к фармацевтической композиции их содержащей и к способам лечения злокачественных новообразований с использованием соединения формулы (1). 4 н. и 12 з.п. ф-лы, 6 табл., 458 пр.