PYRIDINO[1,2-A]PYRIMIDONE ANALOGUE USED AS AN MTOR/PI3K INHIBITOR

FIELD: chemistry.SUBSTANCE: invention relates to a new compound of formula (I) or its pharmaceutically acceptable salt possessing the properties of inhibitor mTOR/PI3K. Action of the double inhibitor allows simultaneously blocking multiple signal transduction sites and more efficient prevention of signal transduction, thereby overcoming or delaying the drug resistance, and has a longer and more effective effect in the cancer treatment. In the compound of formula (I)structural unitcan be replaced byor; E is selected from the group consisting of Ccycloalkyl or Calkyl substituted with R, and number Ris 0, 1, 2 or 3, or E is selected from the group consisting ofand, or E is selected from the group consisting ofandoptionally substituted with 1, 2 or 3 R; where zero, one, two or three of Gare selected from N, and the remaining ones are selected from C(R); Gis selected from the group consisting of -C(R)(R)-, -C(=O)N(R)-, -N(R)-, -C(=NR)-, -S(=O)N(R)-, -S(=O)N(R)-, -O-, -S-, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)- and -N(R)C(=O)N(R)-; zero, one or two of Gare selected from N, and the remaining ones are selected from C(R); zero, one, two, three or four of Gare selected from N, and the remaining ones are selected from C(R); Gis selected from N or C(R); zero, one, two or three of Gare selected from the group consisting of -C(=O)N(R)-, -N(R)-, -C(=NR)-, -S(=O)N(R)-, -S(=O)N(R)-, -O-, -S-, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)- and -N(R)C(=O)N(R)-, and the remaining ones are selected from -C(R)(R)-; one of L and Q is -S(=O)NH- and the other is a single bond; or one of L and Q is -S(=O)- and the other is CH; A and T are independently selected from N or CH; one of X and Y is selected from N and the other is selected from C(R); and Z is selected from CH, or X and Y is selected from C(R) and Z is selected from CH; B is selected from the group consisting of -N(R)-; heteroatom or heteroatom group are independently selected from the group consisting of -C(=O)N(R)-, -N(R)-, -C(=NR)-, -S(=O)N(R)-, -S(=O)N(R)-, -O-, -S-, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)- and -N(R)C(=O)N(R)-; each mis independently selected from 0, 1, 2 or 3; Ris independently selected from the group consisting of H, F, Cl, Br, I, OR, N(R)(R), Calkyl,Rand Rare independently selected from the group consisting of H, F, Cl, Br, I, CN, OR, N(R)(R), Calkyl optionally substituted with R,Dis selected from the group consisting of a single bond, -C(R)(R)-, -C(=O)N(R)-, -N(R)-, -C(=NR)-, -S(=O)N(R)-,