ANALGESIC AGENTS BASED ON 5-ARYL-4-BENZOYL-3-HYDROXY-1-(4-GUANIDYLSULFONYLPHENYL)-3-PYRROLIN-2-ONES

FIELD: pharmacology.SUBSTANCE: invention relates to new analgesics based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones. The analgesic activity of compounds I-IIIR=H (I), 4-Cl (II), 4-MeO (III), exceeds the activity of metamizole sodium and is comparable with the action...

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Hauptverfasser:	Bobrovskaya Olga Vasilevna, Yakovlev Igor Borisovich, Gejn Vladimir Leonidovich, Chashchina Svetlana Viktorovna, Kovtonogova Irina Valerevna
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: pharmacology.SUBSTANCE: invention relates to new analgesics based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones. The analgesic activity of compounds I-IIIR=H (I), 4-Cl (II), 4-MeO (III), exceeds the activity of metamizole sodium and is comparable with the action of nimesulide by analgesic action.EFFECT: increased activity of agents.1 tbl Изобретение относится к новым анальгетическим средствам на основе 5-арил-4-бензоил-3-гидрокси-1-(4-гуанидилсульфонилфенил)-3-пирролин-2-онов. Анальгетическая активность соединений I-III превосходит активность метамизола-натрия и по анальгизирующему действию сравнима с действием нимесулида. 1 табл.