MULTI-SUBSTITUTED AROMATIC COMPOUNDS AS THROMBIN INHIBITORS

FIELD: pharmacology.SUBSTANCE: invention relates to a compound of the formula:, and also to pharmaceutical compositions and methods for treatment and prevention of a disease such as thrombotic one.EFFECT: new compounds capable of inhibiting the protease activity of thrombin.15 cl, 3 tbl, 85 ex Изобр...

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Hauptverfasser:	SHORT Kevin Majkl, UILLYAMS Devid Charlz, DATTA Somalee, FAM Son Minkh
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: pharmacology.SUBSTANCE: invention relates to a compound of the formula:, and also to pharmaceutical compositions and methods for treatment and prevention of a disease such as thrombotic one.EFFECT: new compounds capable of inhibiting the protease activity of thrombin.15 cl, 3 tbl, 85 ex Изобретение относится к соединению формулы:, а также к фармацевтическим композициям и способам лечения и профилактики заболевания, такого как тромботическое. Технический результат: получены новые соединения, способные ингибировать протеазную активность тромбина. 4 н. и 11 з.п. ф-лы, 3 табл., 85 пр.