SYNTHETIC INTERMEDIATE COMPOUND 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE THIONUCLEOSIDES COMPOUND AND METHOD FOR THEIR PRODUCTION

SYNTHETIC INTERMEDIATE COMPOUND 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE THIONUCLEOSIDES COMPOUND AND METHOD FOR THEIR PRODUCTION

FIELD: pharmacology.SUBSTANCE: invention relates to a process for preparation of a compound of the formulaand also to a process for the preparation of 1-(2-desoxy-2-halo-4-thio-β-D-arabinofuranosyl) cytosine of the following formula:. In addition, the invention relates to a formulaintermediate.EFFEC...

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Hauptverfasser: NAKAMURA Kouki, MATSUMOTO Takuya, FUDZINO Yuuta, VADA Kendzi, IMOTO Dzuniti, ITO Takayuki, TAKAKHASI Motomasa, SIMAMURA Satosi, YAMANE Takekhiro, VATANABE Katsuyuki, TAKAKHASI Makoto, OKADA Khideki
Format: Patent
Sprache:eng ; rus
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Zusammenfassung:FIELD: pharmacology.SUBSTANCE: invention relates to a process for preparation of a compound of the formulaand also to a process for the preparation of 1-(2-desoxy-2-halo-4-thio-β-D-arabinofuranosyl) cytosine of the following formula:. In addition, the invention relates to a formulaintermediate.EFFECT: new method for preparation of thionucleoside, which is useful as a medicament, is developed.24 cl, 48 ex Изобретение относится к способу получения соединения формулы [1Е]а также к способу получения 1-(2-дезокси-2-галоген-4-тио-β-D-арабинофуранозил)цитозина следующей формулы [14]:Кроме того, изобретение относится к промежуточному соединению формулы [1F]Технический результат: разработан новый способ получения тионуклеозида, который является пригодным в качестве лекарственного препарата. 11 н. и 13 з.п. ф-лы, 48 пр.