QUINOLINES AS FGFR KINASE MODULATORS

FIELD: pharmacology.SUBSTANCE: invention related to a new quinoline derivative of formula(I), where W us -N(R)- or -C(RR)-; each Ris independently selected from halogen, Calkoxy, Y is -E-D; D is phenyl or 5-6-membered monocyclic heterocyclyl, containing one or two heteroatoms selected from N or O, w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SAKSTI Gordon, ANZHIBO Patrik Rene, BERDINI Valerio, VUDKHED Stiven Dzhon
Format: Patent
Sprache:eng ; rus
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:FIELD: pharmacology.SUBSTANCE: invention related to a new quinoline derivative of formula(I), where W us -N(R)- or -C(RR)-; each Ris independently selected from halogen, Calkoxy, Y is -E-D; D is phenyl or 5-6-membered monocyclic heterocyclyl, containing one or two heteroatoms selected from N or O, wherein the mentioned heterocyclyl can be optionally substituted with one group of R; E is a link; Ris hydrogen, Calkyl, hydroxyCalkyl, Calkyl which is substituted with -S(=O)-Calkyl, R; Ris hydroxyl, hydroxyCalkyl, cyanoCalkyl, Calkyl which is substituted with -NRR, Calkyl which is substituted with -C(=O)-NRR; Ris hydrogen; or Rand Rare combined to obtain =O or to obtain =CH-Calkyl which is substituted with R; Ris cyano; Ris Calkynyl, hydroxyCalkyl, hydroxyhaloCalkyl, Calkyl which is substituted with R, Calkynyl which is substituted with R, Calkyl which is substituted with -NRR; Ris 6-membered monocyclic heterocyclyl, containing one O atom; Ris 5- or 6-membered monocyclic heterocyclyl, containing one or two heteroatoms, seleceted from N or O, each is optionally and each is independently substituted with substitute selected from =O, Calkyl, Calkoxy, S(=O)-NRR, Calkyl which is substituted with -NH-S(=O)-haloCalkyl, 6-membered aromatic monocyclic heterocyclyl, containing two N atoms, wherein the mentioned heterocyclyl is optionally substituted with R; each Rand Rindependently represent hydrogen, Calkyl, haloCalkyl; each Rand Rindependently represent Calkyl; Ris Calkoxy; n independently represent a whole number equal to 2, 3 or 4; as well as to its pharmaceutically acceptable salt and to any tautomeric or stereochemically isomeric form thereof. The invention also relates to pharmaceutical compositions based on compound of formula (I), application of the compound of formula (I), method for the prevention or treatment of a disease and product based on the compound of formula (I).EFFECT: new quinoline derivatives are obtained, useful in the treatment of diseases mediated by FGFR kinase.30 cl, 2 tbl, 35 ex Изобретение относится к области органической химии, а именно к новому производному хинолина формулы (I), где W является -N(R)- или -C(RR)-; каждый Rнезависимо выбран из галогена, Салкокси, Y представляет собой -E-D; D представляет собой фенил или 5-6-членный моноциклический гетероциклил, содержащий один или два гетероатома, выбранных из N или О, где указанный гетероциклил может быть необязательно замещен одной группой R; Е представляет собой связь; Rпредставляет собой