SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF HSL, EFFECTIVE FOR DIABETES TREATMENT

FIELD: pharmaceutics.SUBSTANCE: present invention relates to novel compounds of formula (I), as well as to their pharmaceutically acceptable salts possessing activity of HSL inhibitors, to pharmaceutical composition, method of inhibiting of enzyme HSL lipase, as well as to use of disclosed compounds...

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Bibliographische Detailangaben
Hauptverfasser:	Zhan AKKERMANN, Daniel KHUNTSIKER, Mattias NETTEKOVEN, Shtefan BRUGGER, Orilya KONTE, Verner NAJDKHART, Stenli VERTKHAJMER, Tanya SHULTS-GASH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: pharmaceutics.SUBSTANCE: present invention relates to novel compounds of formula (I), as well as to their pharmaceutically acceptable salts possessing activity of HSL inhibitors, to pharmaceutical composition, method of inhibiting of enzyme HSL lipase, as well as to use of disclosed compounds for preparing a drug. Values R, R, R, Cand Care given in the claim.EFFECT: invention discloses spiro-condensed cyclohexane derivatives as inhibitors of HSL, effective for diabetes treatment.24 cl, 377 ex Настоящее изобретение относится к новым соединениям формулы (I), а также к их фармацевтически приемлемым солям, обладающим активностью ингибиторов HSL, к фармацевтической композиции, к способу ингибирования фермента липазы HSL, а также к применению предлагаемых соединений для изготовления лекарственного средства. Значения R, R, R, Cи Cтакие, как указаны в формуле изобретения. 4 н. и 20 з.п. ф-лы, 377 пр.