NOVEL IMMUNE SYSTEM MODULATORS RELATED APPLICATIONS

FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of formula I or a pharmaceutically acceptable salt thereof, which possess properties of TOLL-like receptor (TLR9) inhibitor and can be used for treating autoimmune diseases, mediated by TLR9 activity. Diseases can be selected from cutaneous and systemic lupus erythematosus, insulin-dependent diabetes mellitus, rheumatoid arthritis, multiple sclerosis, atherosclerosis, psoriasis, psoriatic arthritis, inflammatory bowel disease, ankylosing spondylitis, autoimmune hemolytic anemia, Behget's syndrome, Goodpasture's syndrome, Graves' disease, Guillain-Barre syndrome, Hashimoto's thyroiditis, idiopathic thrombocytopenia, myasthenia gravis, pernicious anemia, polyarteritis nodosa, polymyositis/dermatomyositis, primary biliary sclerosis, sarcoidosis, sclerosing cholangitis, Sjogren's syndrome, systemic sclerosis (scleroderma and CREST syndrome), Takayasu's arteritis, temporal arteritis, and Wegener's granulomatosis. In Formula IX is absent or denotes aryl; Q is H, (CH)NRR, SRor CRRR, where q is equal to 0 or 1; R, Rand R, each independently, represent hydrogen, C-Calkyl, or Rand Rtogether with a nitrogen atom, with which they are bonded form a 6-member heterocycle, containing two nitrogen atoms or a nitrogen atom and an oxygen atom, which can be optionally substituted with (C-C)alkyl or (CH)OR, where p is equal to 2-4; Ris NRR; Rand R, each independently represent (C-C)alkyl, or Rand R, together with a nitrogen atom with which they are bonded, formor 6-member heterocycle containing 1-2 heteroatoms selected from a group consisting of O and N, and which can be optionally substituted with (C-C)alkyl; Y is NR, where Ris hydrogen or (C-C)alkyl; L is an alkyl or alkenyl, each containing from 2 to 10 carbon atoms; Ris hydrogen, halogen, CF, OR, SR, NRRor NH(CH)NRR; Ris a halogen, (C-C)alkyl, CF, phenyl, phenyl substituted with halogen, CN or CF, or NH(CH)NRR; in each case Rindependently represents hydrogen, (C-C)alkyl; and said Rand R, together with a nitrogen atom with which they are bonded, optionally form 5-6-member heterocycle, containing 1-2 heteroatoms selected from O and N, where heterocycle is optionally substituted with (C-C)alkyl; provided that if Rand Rdenote H or methyl, then Q is not H.EFFECT: obtaining novel compounds of formula.19 cl, 5 tbl, 73 ex Изобретение относится к новым соединениям Формулы I или его фармацевтически приемлемой соли, которые обладают свойствами ингибитора TOLL-подобных р