C-4" POSITION SUBSTITUTED MACROLIDE DERIVATIVE

FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) and pharmaceutically acceptable salts thereofwhere Me denotes a methyl group, Ris a hydrogen atom, Calkyl group (Calkyl group can be substituted with one substitute selected from hydroxy group, Calkoxy group, diCalkylamino group and group, presented by formula -NRCORor formula -NRSOR, where Rand Rrepresent a hydrogen atom and Rand R, which can be identical or different, denote a hydrogen atom or Calkyl group) or Calkylsulphonyl group, Rrepresents a hydrogen atom, 4-8-member saturated heterocyclic group with one heteroatom selected from nitrogen atoms (saturated heterocyclic group can be substituted with one substitute selected from phenyl Calkyl group and Calkyl group), Calkanoyl group (Calkanoyl group can be substituted with an amino group or diCalkylamino group) or Calkyl group which can be substituted with 1-3 substitutes selected from a group of substitutes 1, or Rand Rmay be combined together with a nitrogen atom to which they are bonded to form a 4-8-member saturated nitrogen-containing heterocyclic group, which can additionally contain 1 heteroatom selected from a nitrogen atom (saturated nitrogen-containing heterocyclic group can be substituted with 1 substitute selected from hydroxy group, amino group, diCalkylamino group and Calkyl group (Calkyl group can be substituted with diCalkylamino group)). Values of other substitutes are given in patent claim. Invention also relates to a medicinal agent as a macrolide antibiotic for prevention and/or therapeutic treatment of various microbial infectious diseases, containing disclosed compound as an active ingredient, and to a compound of formula (VIII).EFFECT: technical result is obtaining novel compounds having strong antibacterial activity.20 cl, 22 tbl, 576 ex Изобретение относится к соединению формулы (I) и его фармацевтически приемлемым солямгде Me представляет собой метильную группу, Rпредставляет собой атом водорода, Салкильную группу (Cалкильная группа может быть замещена одним заместителем, выбранным из гидроксигруппы, Cалкоксигруппы, диСалкиламиногруппы и группы, представленной формулой -NRCORили формулой -NRSOR, где Rи Rпредставляют собой атом водорода и Rи R, которые могут быть одинаковыми или разными, представляют собой атом водорода или Салкильную группу) или Cалкилсульфонильную группу, Rпредставляет собой атом водорода, 4-8-членную насыщенную гетероциклическую группу с одним гетероатомом, выбранным из атома азота (на