METHOD FOR DIAGNOSIS OF MACROPHAGE ACTIVATION SYNDROME IN PATIENTS WITH ACTIVE SYSTEM JUVENILE IDIOPATHIC ARTHRITIS

FIELD: medicine.SUBSTANCE: method relates to paediatric rheumatology, immunology and haematology and can be used for early diagnosis of severe life-threatening complication of systemic juvenile idiopathic arthritis (SJIA) - macrophage activation syndrome (MAS). Method comprises analysis of biochemical parameters of blood and urine. In presence of at least three values of following parameters: reduced number of platelets ≤211×109/l, reduced number of leukocytes ≤9.9×109/l, increased AST>59.7 E/l, increased LDG>882 E/l, reduced albumin ≤29 g/l, increased ferritin >400 mcg/l, reduced fibrinogen ≤1.8 g/l and the presence of proteinuria 59,7 Е/л, повышение ЛДГ>882 Е/л, снижение альбумина ≤29 г/л, повышение ферритина >400 мкг/л, снижение фибриногена ≤1,8 г/л и наличие протеинурии