METHOD OF OBTAINING NANOCAPSULES OF ANTIBIOTICS IN KONJAC GUM

FIELD: medicine.SUBSTANCE: invention represents method of preparation encapsulation by method of precipitation with non-solvent, characterised by the fact that antibiotics are used as nanocapsule cores, and as shell used is konjac gum, which is precipitated from suspension in hexane by addition of 1...

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Hauptverfasser:	KROLEVETS ALEKSANDR ALEKSANDROVICH, BOGACHEV IL'JA ALEKSANDROVICH, MEDVEDEVA JANA VLADIMIROVNA, BOJKO EKATERINA EVGEN'EVNA, NIKITIN KIRILL SERGEEVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT THEREOF MEDICAL OR VETERINARY SCIENCE NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	FIELD: medicine.SUBSTANCE: invention represents method of preparation encapsulation by method of precipitation with non-solvent, characterised by the fact that antibiotics are used as nanocapsule cores, and as shell used is konjac gum, which is precipitated from suspension in hexane by addition of 1,2-dichloroethane as non-solvent at temperature 25°C.EFFECT: simplification and acceleration of process of obtaining nanocapsules, reduction of loss in the process of obtaining nanocapsules.10 ex Изобретение относится к химико-фармацевтической промышленности и представляет собой способ инкапсуляции препарата методом осаждения нерастворителем, отличающийся тем, что в качестве ядер нанокапсул используются антибиотики, в качестве оболочки - конжаковая камедь, которую осаждают из суспензии в гексане путем добавления 1,2-дихлорэтана в качестве нерастворителя при температуре 25°С. Изобретение обеспечивает упрощение и ускорение процесса получения нанокапсул, уменьшение потерь при получении нанокапсул (увеличение выхода по массе). 10 пр.