NOVEL CRYSTALLINE FORMS OF 4,4'-[4-FLUORO-7({4-[4-(3-FLUORO-2-METHYLPHENYL)BUTOXY]PHENYL} ETHYNYL)-2-METHYL-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID, 4,4'-[2-METHYL-7-({4-[4-(PENTAFLUOROPHENYL)BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID AND 4,4'-[4-FLUORO-2-METHYL-7-({4-[4-(2,3,4,6-TETRAFLUOROPHENYL) BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID

FIELD: chemistry.SUBSTANCE: invention relates to novel crystalline forms of 4,4'-[4-fluoro-7-({4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl}ethynyl)-2-methyl-1H-indole-1,3-diiyl]dibutanoic acid, 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	TAKEHUTI DZJUN, NEHKADO TAKAKHIRO, UEHDA DZJUNJA, FUDZITA MANABU, ONO SIDZUKA, ITADANI SATOSI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	FIELD: chemistry.SUBSTANCE: invention relates to novel crystalline forms of 4,4'-[4-fluoro-7-({4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl}ethynyl)-2-methyl-1H-indole-1,3-diiyl]dibutanoic acid, 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid and 4,4'-[4-fluoro-2-methyl-7-({4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid.EFFECT: obtaining novel compounds.18 cl, 16 dwg, 7 tbl, 24 ex Изобретение относится к новым кристаллическим формам 4,4′-[4-фтор-7-({4-[4-(3-фтор-2-метилфенил)бутокси]фенил}этинил)-2-метил-1Н-индол-1,3-диил]дибутановой кислоты, 4,4′-[2-метил-7-({4-[4-(пентафторфенил)бутокси]фенил}этинил)-1Н-индол-1,3-диил]дибутановой кислоты и 4,4′-[4-фтор-2-метил-7-({4-[4-(2,3,4,6-тетрафторфенил)бутокси]фенил}этинил)-1Н-индол-1,3-диил]дибутановой кислоты. 6 н. и 12 з.п. ф-лы, 16 ил., 7 табл., 24 пр.