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FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula:Iwhere (a) X is N or CR8; (b) R1 is H, F, Cl, Br; (c) R2 is H; (d) R3 is H, F, Cl, Br; (e) R4 is H, F, Cl, Br, I, CN, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-...

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Hauptverfasser: CHZHAN JUJ, JAP MORIS, GARITSI NEGAR, MAKLAUD KASANDRA, TRALLINGER TONI, DZHONSON PITER, NIJAZ NOORMOKHAMED, DEAMIKIS KARL, PERNIKH DEHN, DZHONSON TIMOTI, PARKER MARSHALL, ROSS RONAL'D, KHANTER RIKI, BRAJAN KRISTI, CHZHU JUAN'MIN, EHKKEL'BARDZHER DZHOZEF, BAJSS EHNN
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula:Iwhere (a) X is N or CR8; (b) R1 is H, F, Cl, Br; (c) R2 is H; (d) R3 is H, F, Cl, Br; (e) R4 is H, F, Cl, Br, I, CN, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-aryl, SR9, where each of said R4, which is substituted, contains one or more substitutes selected from F, Cl, Br; (f) R5 is H, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, C(=X1)R9, C(=X1)OR9, C-CalkylC-aryl (where the aryl can be substituted or unsubstituted), R9X2C(=X1)R9, R9X2R9, C(=O)(C-Calkyl)S(O)(C-Calkyl), C(=O)(C-Calkyl)C(=O)O(C-Calkyl), (C-Calkenyl)C(=O)O(C-Calkyl), SR9, R9S(O)R9; where each of said R5, which is substituted, contains one substitute selected from F, Cl, Br, C-Ccycloalkyl, OR9, optionally, R5 and R7 can be bonded to form a Ccyclic system; (g) R6 is O, S, NR9; (h) R7 is substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkoxy, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-aryl, substituted or unsubstituted C-Cheterocyclyl, selected from thiazole, oxazole, isothiazole, thiophene, pyrroidine, furan, tetrahydrothiophene, pyridazine, piperdine, pyrazole, OR9, OR9S(O)R9, C(=X1)R9, R9C(=X1)OR9, N(R9), N(R9)(R9S(O)R9), SR9, R9S(O)R9, C-CalkylC-Cheterocyclyl (where the heterocyclyl is selected from triazole and pyrazole), C-CalkylS(=N-CN)(C-Calkyl), C-CalkylS(O)(=N-CN)(C-Calkyl), C-CalkylNH(C(=O)OC-Calkyl), C-CalkylC(=O)OC-Calkyl, C-Calkyl(C-aryl)NH(C(=O)OC-Calkyl), C-Calkyl(S-C-Calkyl)NH(C(=O)OC-Calkyl), C-Calkyl(S-C-Calkyl-C-aryl)NH(C(=O)OC-Calkyl), C-Calkyl(NHC(=O)OC-CalkylC-aryl)NH(C(=O)OC-Calkyl), C-Calkyl(OC-CalkylC-Caryl)NH(C(=O)OC-Calkyl), C-CalkylNH(C-Calkyl)(C(=O)OC-Calkyl), C-CalkylNH(C-Calkyl), C-CalkylN(C-Calkyl)(S(O)C-Calkyl), C-CalkylN(C-Calkyl)(S(O)C-CalkenylC-aryl), C-CalkylN(C-Calkyl)(C(=O)C-Cheterocyclyl) (where the heterocyclyl is selected from pyrazole or thiophene), C-CalkylN(C-Calkyl)(C(=O)OC-CalkylC-aryl), NH(C-CalkylS(O)C-Calkyl), where each of said R7, which is substituted, contains one or more substitutes selected from F, Cl, Br, C-Calkyl, C-Ccycloalkyl, C(=X1)R9, C(=X1)OR9, =X2, S(=X2)R9; (i) R8 is H, F, Cl, Br, I, CN, unsubstituted C-Calkoxy, C(=X)OR9, S(O)R9; (j) R9 (each independently) is H, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubsti