NOVEL BENZODIAZEPINE DERIVATIVES

FIELD: chemistry.SUBSTANCE: invention relates to compound of formula:double linebetween N and C represents double bond, X is absent, a Y stands for H; W stands for C=O; each of R, R, R, Rstands for H; Ris selected from groups OR, where Rhas the same determination as R; optionally Rstands for binding group or is selected from groups: polypyrrole, polyindolyl, polyimidazolyle, polypyrrole-imidazolyle, polypyrrole-indolyl or polyimidazole-indolyl unit, optionally bound to binding groups; Rstands for OR or optionally, Rstands for binding group; Z is selected from groups (CH), where n stands for 1, 2 or 3, CRR, where each of Rand Rindependently stands for H or linear alkyl, having from 1 to 10 carbon atoms; R stands for H or linear or branched alkyl, having from 1 to 3 carbon atoms, optionally substituted with group -COR; Rstands for H or -OR; and Rstands for H or linear or branched alkyl, having from 1 to 3 carbon atoms; each of R, R, R, R, R', R', R' and R' stands for H, optionally any of R, R, R, R, R', R', R' or R' stands for binding group, Z is selected from groups (CH), where n stands for 1, 2 or 3; Rstands for OR, or optionally Rstands for binding group; A and A? stand for O, D and D', similar or different, and independently represent linear or branched alkyls, having from 1 to 10 carbon atoms; L is absent or stands for phenyl group, where said phenyl group representing L, is optionally substituted, where substituent is represented by binding group or is selected from OR, NRR, NRCOR' or OCOR; R and R' independently represent H or linear or branched alkyl, having from 1 to 10 carbon atoms, optionally substituted with halogen or group -COR; R, R, Rand Rindependently represent H or linear or branched alkyl, having from 1 to 10 carbon atoms, or polyethylene glycol unit (-OCHCH), where n stands for integer number from 1 to 10; on condition that said compound has not more than one binding group, which provides bond with cell-binding agent due to covalent bond, which possess anti-proliferative activity.EFFECT: obtaining novel compounds.24 cl, 59 dwg, 9 tbl, 40 ex Изобретение относится к соединениям формулы (I), (II), (IV) или (V):двойная линиямежду N и C представляет собой двойную связь, X отсутствует, а Y является Н; W является С=O; каждый из R, R, R, Rявляется Н; Rвыбран из групп OR, где Rимеет то же определение, что и R; необязательно Rявляется связывающей группой или выбран из групп: полипирроловое, полииндолиловое, полиимидазолиловое, полипирроло-имидазоли