5-HT RECEPTOR MODULATORS AND METHODS FOR USING THEM

FIELD: medicine, pharmaceutics.SUBSTANCE: in general formula, fragment A is specified in a group consisting of,or, R, R, Rand Rmean hydrogen or alkyl; each of Rand Rrepresents hydrogen; Grepresents aryl or heteroaryl, which can by unsubstituted or substituted by 1, 2, 3, 4 or 5 substitutes specified in a group consisting of alkyl, halogen, cyano, -OR, -S(O)R, -C(O)R, -C(O)OR, -OC(O)N(R)(R), -(CRR)-OR, -C(OH)[(CRR)-R], and halogenalkyl; Gmeans cycloalkyl, cycloalkenyl or heterocycle unsubstituted or substituted by 1, 2, 3, 4 or 5 substitutes specified in a group consisting of alkyl; Rrepresents hydrogen or alkyl; Rand Rrepresents hydrogen, alkyl or halogenalkyl; Rrepresents alkyl; Rand Rrepresents hydrogen, halogen, alkyl or halogenalkyl; m represents 1, 2, 3, 4 or 5; Ris specified in a group consisting of hydrogen, alkyl, -(CRR)-Gand -S(O)R, Rrepresents G, Xmeans N or CR; Xmeans N or CR; Xmeans CR; Xmeans N or CR; provided one fragment of X, Xor Xcan represent N; each of R, R, R, R, Rand Rindependently represents hydrogen, alkyl, alkenyl, halogen, -G, -G, -OR, -C(O)G, -C(O)OR, -C(O)N(R)(R), -N(R)(R), -(CRR)-G, -CR=CR-G, -(CRR)-G, -CR=C(R), halogenalkyl and fragment; Rand Rrepresents hydrogen, alkyl, haloalkyl, G, -(CRR)-G, Gor -(CRR)-G; Ris alkyl or halogenalkyl; Rrepresents hydrogen, alkyl or helogenalkyl; Grepresents heterocycle attached to an adjoining carbonyl fragment through a nitrogen atom being a part of heterocycle; or Rand Ror Rand Rtogether with carbon atoms which they are attached to, form unsubstituted phenyl or cycloalkyl; Ymeans NR, CRR, C(O), S(O)or O; Ymeans NR, CRRor C(O); Ymeans NR, CRRor C(O); or Yand Ytogether represent CR=CR, n means 2; Rrepresents hydrogen; Rand Rrepresents hydrogen; and Ris specified in a group consisting of hydrogen, alkyl and -S(O)-G.EFFECT: invention refers to compounds of formula (I) and their pharmaceutically acceptable salts possessing the properties of a 5-HTand/or 5-HTreceptor modulator, to a based pharmaceutical composition and to methods for preparing them.33 cl, 7 tbl, 20 dwg, 278 ex Изобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солям, обладающим свойствами модулятора рецептора 5-HTи/или 5-НТ, фармацевтической композиции на их основе и способам их получения. В общей формуле (I) фрагмент А выбран из группы, состоящей из (i), (ii) или (iii), R, R, Rи Rозначают водород или алкил; каждый из Rи Rпредставляет собой водород; Gпредставляет собой арил или гетероарил, который может