PHOSPHORUS-CONTAINING FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES, POSSESSING CYTOTOXIC ACTIVITY WITH RESPECT TO HUMAN CANCER CELLS IN CULTURE

FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel fluorinated 1,4-naphthoquinone derivatives of general formula, where 1 R=CH, X=F; 2 R=2, 5-FCH, X=F; 3 R=CH, X=F; 4 R=CH, X,, possessing cytotoxic activity with respect to cancer cells, which can be applied in medicine.EFFECT: clai...

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Hauptverfasser:	ZAKHAROVA OL'GA DMITRIEVNA, NEVINSKIJ GEORGIJ ALEKSANDROVICH, SHTEJNGARTS VITALIJ DAVIDOVICH, GORJUNOV LEONID IVANOVICH, ZHIVET'EVA SVETLANA IVANOVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel fluorinated 1,4-naphthoquinone derivatives of general formula, where 1 R=CH, X=F; 2 R=2, 5-FCH, X=F; 3 R=CH, X=F; 4 R=CH, X,, possessing cytotoxic activity with respect to cancer cells, which can be applied in medicine.EFFECT: claimed are novel compounds with anti-cancer activity for therapy of malignant neoplasms.1 dwg, 3 tbl, 5 ex Изобретение относится к новым фторированным производным 1,4-нафтохинона общей формулы (I)обладающим цитотоксической активностью по отношению к раковым клеткам, которые могут найти применение в медицине. Предложены новые соединения с противораковой активностью для терапии злокачественных новообразований. 1 ил., 3 табл., 5 пр.