PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel compounds of formula,where values A, R-Rare given in i.1 of the invention formula. Methods of obtaining the formula (I) compound are described.EFFECT: compounds demonstrate an inhibiting activity of the cathepsin enzyme, which make...
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| creator | GUIDO KHARTMANN SIMONA M. CHEKKARELLI KHARAL'D MAUZER UVE GRETER KHANS KHIL'PERT VOL'FGANG KHAP RUBEN AL'VARES-SANCHES PITER KHARTMEN DEJVID BANNER KHOL'GER KJUNE ZHAN-MARK PLANSHE |
| description | FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel compounds of formula,where values A, R-Rare given in i.1 of the invention formula. Methods of obtaining the formula (I) compound are described.EFFECT: compounds demonstrate an inhibiting activity of the cathepsin enzyme, which makes it possible to use them for the preparation of a pharmaceutical composition and for the preparation of a medication.38 cl, 12 dwg, 495 ex
Изобретение относится к новым соединениям формулыгде значения A, R-Rприведены в п.1 формулы изобретения. Соединения проявляют ингибирующую активность фермента катепсина, что позволяет использовать их для приготовления фармацевтической композиции и для приготовления лекарственного средства. Описаны способы получения соединения формулы (I). 8 н. и 30 з.п. ф-лы, 12 схем, 495 пр. |
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Изобретение относится к новым соединениям формулыгде значения A, R-Rприведены в п.1 формулы изобретения. Соединения проявляют ингибирующую активность фермента катепсина, что позволяет использовать их для приготовления фармацевтической композиции и для приготовления лекарственного средства. Описаны способы получения соединения формулы (I). 8 н. и 30 з.п. ф-лы, 12 схем, 495 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS |
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