PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS

FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel compounds of formula,where values A, R-Rare given in i.1 of the invention formula. Methods of obtaining the formula (I) compound are described.EFFECT: compounds demonstrate an inhibiting activity of the cathepsin enzyme, which make...

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Bibliographische Detailangaben
Hauptverfasser:	GUIDO KHARTMANN, SIMONA M. CHEKKARELLI, KHARAL'D MAUZER, UVE GRETER, KHANS KHIL'PERT, VOL'FGANG KHAP, RUBEN AL'VARES-SANCHES, PITER KHARTMEN, DEJVID BANNER, KHOL'GER KJUNE, ZHAN-MARK PLANSHE
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel compounds of formula,where values A, R-Rare given in i.1 of the invention formula. Methods of obtaining the formula (I) compound are described.EFFECT: compounds demonstrate an inhibiting activity of the cathepsin enzyme, which makes it possible to use them for the preparation of a pharmaceutical composition and for the preparation of a medication.38 cl, 12 dwg, 495 ex Изобретение относится к новым соединениям формулыгде значения A, R-Rприведены в п.1 формулы изобретения. Соединения проявляют ингибирующую активность фермента катепсина, что позволяет использовать их для приготовления фармацевтической композиции и для приготовления лекарственного средства. Описаны способы получения соединения формулы (I). 8 н. и 30 з.п. ф-лы, 12 схем, 495 пр.