ACYLAMINO-SUBSTITUTED DERIVATIVES OF CONDENSED CYCLOPENTACARBOXYLIC ACIDS AND THEIR APPLICATION AS PHARMACEUTICALS

FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compound of formula (I), where ring A is cycloalkane ring with number of members from 3 to 7, benzene ring or monocyclic 5-member or 6-member aromatic heterocyclic ring, containing 1 heteromember of ring, selected from the group, containing N and S, and benzene and heterocyclic rings can optionally have one or two similar or different substituents, selected from the group, containing halogen, HO-, R-O-, HN-C(O)- and NC-; Y is selected from the group, containing S, C(R)=C(R) and C(R)=N; Z is selected from the group, containing C(R); R, R, R, R, Rand Rindependently on each other group R, R, R, R, Rand Rare selected from the group, containing (C-C)-alkyl, (C-C)-alkenyl, (C-C)-cycloalkyl and (C-C)-cycloalkyl-(C-C)-alkyl-, and all of them can optionally have one or more similar or different substituents R; Rand Rrepresent hydrogen; Rand Rare selected independently on each other, from the group, containing hydrogen and , (C-C)-alkyl; R, R, Rand Rare selected independently on each other, from the group, containing hydrogen, halogen and ON-; Ris selected from the group, containing hydrogen and (C-C)-alkyl; one of the groups Rand Ris group of formula II: R-R-, and the other of groups Rand Ris selected from the group, containing hydrogen, halogen, R, HO-, R-O-, R-S(O)-, HN-, R-NH-, R-N(R)-, R-C(O)- and NC-; Ris chain, containing from 1 to 5 chain members of which 0 or 1 chain member is heteromember of chain, selected from the group, containing N(R), O, S, with other chain members being similar or different groups C(R)(R), where two adjacent groups can be bound to each other by double bond; Ris selected from the group, containing hydrogen, R, R-O-, R-NH-, R-N(R)-, R-C(O)-NH-, HO-C(O)- and monocyclic, bicyclic or tricyclic ring with number of members from 5 to 10, which is saturated or non-saturated and contains 0, 1, 2 or 3 similar or different ring heteromembers, selected from the group, containing N, N(R), O, S, and ring can optionally have on ring carbon atoms one or 2-3 similar or different substituents, selected from the group, containing halogen, R, R-O-, R-S(O)-, R-C(O)-NH-, R-S(O)-NH-, R-C(O)-, HO-C(O)-, HN-C(O)-, R-NH-C(O)-, R-N(R)-S(O)-, NC-, oxo, phenyl and Het; on condition that total number of C, N, O and S atoms, present in two groups Rand R, constitutes not less than 5; Ris selected from the group, containing hydrogen and (C-C)-alkyl; R, independently on each other group R, is selected from