INHIBITORS OF HUMAN POLY(ADP-RIBOSO)POLYMERASE-1 BASED ON URACYL DERIVATIVES

FIELD: chemistry.SUBSTANCE: invention relates to novel inhibitors of human poly(ADP-riboso)polymerase-1 based on uracyl derivatives of general formula (I), (II), (III) and (IV). Inhibitors of poly(ADP-riboso)polymerase-enzymes take part in DNA reparation. In general formulaandR=H, Cl, Br, I, methyl,...

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Hauptverfasser:	MIKHAJLOV SERGEJ NIKOLAEVICH, DRENICHEV MIKHAIL SERGEEVICH, ZAKHARENKO ALEKSANDRA LEONIDOVNA, TIMOFEEV EHDUARD NIKOLAEVICH, KUROCHKIN NIKOLAJ NIKOLAEVICH, TARAROV VITALIJ IVANOVICH, KHODYREVA SVETLANA NIKOLAEVNA, KOLGANOVA NATAL'JA ANATOL'EVNA, LAVRIK OL'GA IVANOVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: chemistry.SUBSTANCE: invention relates to novel inhibitors of human poly(ADP-riboso)polymerase-1 based on uracyl derivatives of general formula (I), (II), (III) and (IV). Inhibitors of poly(ADP-riboso)polymerase-enzymes take part in DNA reparation. In general formulaandR=H, Cl, Br, I, methyl, ethyl, propyl or isopropyl; R, R, R, R=H, methyl, ethyl, propyl or phenyl; R=(CH), where n=1-4; X=ORor NRR, R, R=H, methyl, ethyl, propyl, phenyl, 3-hydroxypropyl.EFFECT: obtaining novel inhibitors of human poly(ADP-riboso)polymerase-1.1 tbl, 19 ex Изобретение относится к новым ингибиторам поли(АДФ-рибозо)полимеразы-1 человека на основе производных урацила общей формулы (I), (II), (III) и (IV). Ингибиторы поли(АDР-рибозо)полимераз-ферментов участвуют в репарации ДНК. В общей формуле (I), (II), (III) и (IV)R=Н, Cl, Br, I, метил, этил, пропил или изопропил; R, R, R, R=Н, метил, этил, пропил или фенил; R=(СН), где n=1-4; X=ORили NRR, R, R=Н, метил, этил, пропил, фенил, 3-гидроксипропил. 1 табл., 19 пр.