6-SUBSTITUTED 3-AZOLYLIMIDAZO[1,2-b][1,2,4,5]TETRAZINES SHOWING ANTICANCER ACTIVITY

FIELD: chemistry.SUBSTANCE: there are described new derivatives of imidazo[1,2-b][1,2,4,5]tetrazines of general formula (I)wherein: Het=4-methylimidazol-1-yl, R=H or Het=3,5-dimethylpyrazol-1-yl, R=propylthio, and based anticancer agents for treating oncological patients.EFFECT: higher clinical effe...

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Hauptverfasser:	ISHMETOVA RASHIDA IRSHOTOVNA, RUSINOV GENNADIJ LEONIDOVICH, TOLSHCHINA SVETLANA GENNAD'EVNA, CHARUSHIN VALERIJ NIKOLAEVICH, SHTIL' ALEKSANDR AL'BERTOVICH, BEKKER OL'GA BORISOVNA, DANILENKO VALERIJ NIKOLAEVICH, IGNATENKO NINA KONSTANTINOVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: chemistry.SUBSTANCE: there are described new derivatives of imidazo[1,2-b][1,2,4,5]tetrazines of general formula (I)wherein: Het=4-methylimidazol-1-yl, R=H or Het=3,5-dimethylpyrazol-1-yl, R=propylthio, and based anticancer agents for treating oncological patients.EFFECT: higher clinical effectiveness.2 cl, 1 tbl, 2 ex Описываются новые производные имидазо[1,2-b][1,2,4,5]тетразинов общей формулыгде: Het=4-метилимидазол-1-ил, R=Н или Het=3,5-диметилпиразол-1-ил, R=пропилтио, и противоопухолевые агенты на их основе для лечения онкологических больных. 2 н.п. ф-лы, 1 табл., 2 пр.