METHOD FOR ASSESSING PROBABILITY OF BIRTH DEFECTS IN PREGNANT WOMEN

FIELD: medicine.SUBSTANCE: blood is sampled; a molecular-genetic analysis is used to determine genetic polymorphisms in detoxification enzyme GSTT1 in lymphocytic DNA. That is followed by an enzyme-immunoassay of immunoglobulins A and G - IgA, IgG specific to benzo[a]pyrene Bp, oestradiol Es and pro...

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Hauptverfasser:	GLUSHKOV ANDREJ NIKOLAEVICH, ANOSOVA TAT'JANA PETROVNA, GORDEEVA LJUDMILA ALEKSANDROVNA, POPOVA OL'GA SERGEEVNA, SHATALINA IRINA VIKTOROVNA, POLENOK ELENA GENNAD'EVNA, DRUZHININ VLADIMIR GENNAD'EVICH, KRASIL'NIKOVA KSENIJA SERGEEVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	FIELD: medicine.SUBSTANCE: blood is sampled; a molecular-genetic analysis is used to determine genetic polymorphisms in detoxification enzyme GSTT1 in lymphocytic DNA. That is followed by an enzyme-immunoassay of immunoglobulins A and G - IgA, IgG specific to benzo[a]pyrene Bp, oestradiol Es and progesterone Pg in blood serum that are used as measurements of the body immunological response to the effect of teratogens. If observing an increase of the relations of immunoglobulins IgA Bp/Es>2, IgA Bp/Pg>2, IgG Bp/Es>2, IgG Bp/Pg>3 in GSTT1 0/0 genotype carriers, a high individual responsiveness of the pregnant woman to the effect of teratogens is stated. In this regard, a high probability of birth defects is predicted. If observing a decrease of the relations of immunoglobulins IgA Bp/Es3 у носителей генотипа GSTT1 «0/0» делают вывод о высокой индивидуальной чувствительности беременной женщины к действию тератогенных факторов. В связи с этим делают прогноз о высокой вероятности возникновения врожденных пороков развития плода. При определении пониженных значений соотношений уровней антител IgA Bp/Es