CETP INHIBITORS

FIELD: chemistry.SUBSTANCE: invention relates to compound of formulaI, or its pharmaceutically acceptable saltwhere: X stands for -O-; Z stands for -C(=O)-; Y stands for -(CRR)-, where Ris selected from -C-Calkyl; R stands for H or -C-Calkyl; Rstands for H; Rand B each is selected from Aand A, where one of Rand B stands for A, and the other from Rand B stands for A; where Ahas structure (a); Ais selected from the group, which includes phenyl, pyridyl, pyrazolyl, thienyl, 1,2,4-triazolyl and imodazolyl; Ais selected from the group including phenyl, thiazolyl and pyrazolyl; Ais selected from the group, including phenyl, pyridyl, thiazolyl, pyrazolyl, 1,2,4-triazolyl, pyrimidinyl, piperidinyl, pyrrolidinyl and asetidinyl; Ais optionally substituted with 1-3 substituents, independently selected from halogen atom, -OCHand -OCFand -C-Calkyl, optionally substituted with 1-3 halogen atoms; Ais substituted with one Agroup and is optionally substituted with 1-2 substituents, independently selected from halogen atom, -OH, -OCH, -OCFand -C-Calkyl, optionally substituted with 1-3 halogen atoms; Ais optionally substituted with 1-3 substituents, independently selected from the group, which includes: (a) -C-Calkyl, optionally substituted with 1-3 halogen atoms and optionally substituted with group -OH, (b) -C-Calkenyl, optionally substituted with 1-3 halogen atoms, (c) -C(=O)C-Calkyl, optionally substituted with 1-3 halogen atoms and optionally substituted with one group selected from -OH, -COCH, -C(=O)CH, -NRRand -OC-CalkyleneOC-Calkyl, (d) -C(=O)H, (e) -COH, (f) -COC-Calkyl, optionally substituted with one group, selected from -C(=O)C-Calkyl, -OH, -COCH, -COH, -NRRand -OC-CalkyleneOC-Calkyl, (g) -OH, (h) -S(O)C-Calkyl, (i) halogen atom, (j) -CN, (k) -NO, (l) -C(=O)NRR, (m) -OC-CalkyleneOC-Calkyl, (n) -OC-Calkyl, optionally substituted with 1-3 halogen atoms, (o) -C(=O)OC-Calkyl, optionally substituted with 1-3 halogen atoms and optionally substituted with one group, selected from -OH, -COCH, -NRRand -OC-CalkyleneOC-Calkyl, (q) -NRRand (r) -S(O)NRR, on condition that Astands for heterocyclic group, attached to Aby means of ring carbon atom in A, at least, one substituent in Amust be selected from R, where Ris selected from the group including: (a) -C-Calkyl, substituted with -OH group and optionally substituted with 1-3 halogen atoms, (b) -C-Calkenyl, optionally substituted with 1-3 halogen atoms, (c) -C(=O)C-Calkyl, optionally substituted with 1-3 halogen atoms and opti