4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES

FIELD: chemistry.SUBSTANCE: invention relates to application of compounds of formulaI, where Rrepresents hydrogen atom, C-alkyl, C-alkoxy, C-alkyl, substituted with halogen atom, C-alkoxy, substituted with halogen atom, halogen atom, cyano, nitro, hydroxy, C(O)O-C-alkyl, S(O)-C-alkyl, C(O)OCH-phenyl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GREBKE TSBINDEN KATRIN, GALLEJ GUIDO, NORKROSS RODZHER, GERGLE ANNIK
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: chemistry.SUBSTANCE: invention relates to application of compounds of formulaI, where Rrepresents hydrogen atom, C-alkyl, C-alkoxy, C-alkyl, substituted with halogen atom, C-alkoxy, substituted with halogen atom, halogen atom, cyano, nitro, hydroxy, C(O)O-C-alkyl, S(O)-C-alkyl, C(O)OCH-phenyl, OCH-phenyl, tetrazol-1-yl, phenyl, possibly substituted with halogen atom, or represents phenyloxy, possibly substituted with halogen atom, or represents benzyl, possibly substituted with halogen atom, or represents benzyloxy, possibly substituted with halogen atom; in case, when n>1, Rsubstituents can be similar or different; X represents -O-(CH)-, -O-CHR"-CH-, -O-CH-CHR', -O-CR"-CH-, -(CH)-CHR'-, -CHR'-(CH)-, -CR"-(CH)-, -CH-CHR'-CH-, -CH-CR"-CH-, -CHR"-O-CH-, -CR"-O-CH-, -CF(CH)-, -CR"-CH-, -SiR"-(CH)-, -S-(CH)-, -S(O)-(CH)-, -(CH)-, -CH-O-(CH)-, formula(a) or(b), where m has value 0, 1, 2 or 3; R' represents C-alkyl, C-alkoxy or C-alkyl, substituted with halogen atom; R" represents C-alkyl or C-alkyl, substituted with halogen atom; Rrepresents hydrogen atom or C-alkyl; Y represents phenyl, naphthyl, C-cycloalkyl or pyridin-2- or 3-yl, pyrimidin-2-yl or quinolin-6 or 7-yl; n has value 1, 2 or 3; or pharmaceutically acceptable salt of acid attachment in manufacturing medication for treatment anxiety disorders, bipolar disorder, stress-induced disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson disease, neurodegenerative disorders, Alzheimer's disease, epilepsy and migraine. Invention also relates to compounds of formula I, where Rrepresents hydrogen atom, C-alkyl, C-alkoxy, C-alkyl, substituted with halogen atom, C-alkoxy, substituted with halogen atom, halogen atom, cyano, nitro, hydroxy, C(O)O-C-alkyl, S(O)-C-alkyl, C(O)OCH-phenyl, OCHphenyl, tetrazol-1-yl, phenyl, possibly substituted with halogen atom, or represents phenyloxy, possibly substituted with halogen atom, or represents benzyl, possibly substituted with halogen atom, or represents benzyloxy, possibly substituted with halogen atom; in case when n>1, Rsubstituents can be similar or different; X represents -(CH)-CHR', -CHR'-(CH)-, -CR"-(CH)-, -CH-CHR'-CH-, -CH-CR"-CH-, -CF(CH)-, formula (a), where m has value 0, 1, 2 or 3; R' represents C-alkyl, C-alkoxy or C-alkyl, substituted with halogen atom; R" represents C-alkyl or C-alkyl, substituted with halogen atom; Rrepresents hydrogen atom or C-alkyl; Y represents phenyl, naphthyl, C-cycloalkyl or pyridin-2- or 3-yl, pyrimi