SUBSTITUTED SULPHONAMIDE DERIVATIVES

FIELD: chemistry.SUBSTANCE: invention relates to substituted sulphonamide derivatives of general formula:where m equals 0, 1 or 2; n equals 1 or 2; o equals 0, 1 or 2; p equals 0, 1 or 2; q equals 0, 1, 2 or 3; r equals 0, 1 or 2, under the condition that q+r is not greater than 3; v equals 0 or 1; w equals 0 or 1; under the condition that if v equals 0, then w equals 0; Andenotes a halide anion; Q denotes a single bond, -O- or -CH-; Rdenotes aryl; Rand Rhave values given in (i) or (ii): (i) Rdenotes H, C-alkyl, C-cycloalkyl, a bicyclic 8-12-member carbocyclyl, CH(aryl)or aryl; or denotes a heteroaryl bonded through a C-alkylene group, the heteroaryl being selected from pyridinyl; Rdenotes H, C-alkyl or aryl; or (ii) Rand R, together with the -N-(CH-)- group bonding them, form a heterocycle which can be annelated with an aryl residue, where the heterocycle is 6-membered, saturated or at least monounsaturated but not aromatic, and together with the N heteroatom to which the residue Ris bonded, can contain at least another O heteroatom; Rdenotes aryl or heteroaryl, selected from pyridinyl; Rand Rindependently denote H or C-alkyl, wherein Rand Rdo not simultaneously denote H; or Rand Rtogether denote a substituted or unsubstituted 5- or 6-member heteroaryl which, together with an N atom to which Rand Rare bonded, can contain at least another N heteroatom; or Rand Rtogether denote a group selected from -(CH)- or -(CH)-X-(CH), where d denotes 2, 3, 4, 5 or 6 and e and f are independently equal to 1, 2 or 3, under the condition that e+f is not greater than 5; and X denotes NR, where Rdenotes H or C-alkyl; Rdenotes C-alkyl; and where said aryl and heteroaryl residues in case can be unsubstituted or monosubustituted or multi-substituted with the same or different residues selected from a group comprising F, Cl, Br, I, O-C-alkyl, CFand C-alkyl; and said C-alkyl residues in each case can be branched or straight; in form of a separate enantiomer or separate diastereomer, racemate, enantiomers, diastereomers, mixtures of enantiomers and/or diastereomers, and in each case in form of bases and/or physiologically compatible salts thereof. The invention also relates to a method of producing the described compound, a drug having antagonistic action on B1R, based on compounds of formula I and use of said compound to produce a drug.EFFECT: novel compounds which can be used in medicine are obtained and described.15 cl, 131 ex Изобретение относится к замещенным производным сул