DIALKYL(2-METHYL-4-OXOPENT-2-YL)PHOSPHINE OXIDE PYRIDINOYL HYDRAZONES, HAVING ANTITUBERCULOUS ACTIVITY

FIELD: chemistry.SUBSTANCE: invention relates to dialkyl(2-methyl-4-oxopent-2-yl) phosphine oxide pyridinoyl hydrazones (Ia-c) for treating tuberculosis, which can be used in medicine and veterinary:la Py-4-Py, R=Et; Ib Py=4-Py, R=Pr; 1c Py=3-Py, R=Et.EFFECT: novel efficient antituberculous preparat...

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Hauptverfasser:	KOSTIN ANTON ALEKSEEVICH, CHESTNOVA REGINA VALER'EVNA, VALIEV RAVIL' SHAMILOVICH, GARAEV RAMIL SUFIAKHMETOVICH, BUZYKIN BORIS IVANOVICH, KASHAPOV LENAR RAMILOVICH, TATARINOV DMITRIJ ANATOL'EVICH, MIRONOV VLADIMIR FEDOROVICH
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: chemistry.SUBSTANCE: invention relates to dialkyl(2-methyl-4-oxopent-2-yl) phosphine oxide pyridinoyl hydrazones (Ia-c) for treating tuberculosis, which can be used in medicine and veterinary:la Py-4-Py, R=Et; Ib Py=4-Py, R=Pr; 1c Py=3-Py, R=Et.EFFECT: novel efficient antituberculous preparations with low toxicity, which do not exhibit neurotoxic activity.2 cl, 3 ex, 2 tbl Настоящее изобретение относится к пиридиноилгидразонам диалкил(2-метил-4-оксопент-2-ил)фосфиноксидов (Ia-в) для лечения туберкулеза, которые могут применяться в медицине и ветеринарии:Ia Py=4-Py,R=Et;Iб Py=4-Py, R=Рr;Iв Py=3-Py, R=Et.Предложены новые эффективные противотуберкулезные препараты с низкой токсичностью, не проявляющие нейротоксического действия. 1 з.п. ф-лы, 3 пр., 2 табл.