AMIDE OF NONAPEPTIDE PREVENTING INCREASE OF HYPERPERMEABILITY OF VESSEL ENDOTHELIUM

AMIDE OF NONAPEPTIDE PREVENTING INCREASE OF HYPERPERMEABILITY OF VESSEL ENDOTHELIUM

FIELD: biotechnologies.SUBSTANCE: peptide of the formula H-(N-Me)-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-D-Arg-Lys-NHis proposed. The proposed peptide may find application as an agent for reduction of pathological hyperpermeability of vessel endothelium in various areas of medicine (in cardiology, toxicology,...

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Hauptverfasser: ABRAMOV ALEKSANDR ALEKSANDROVICH, BESPALOVA ZHANNA DMITRIEVNA, SAMSONOV MIKHAIL VASIL'EVICH, KAZAKOVA OL'GA ALEKSEEVNA, KHAPCHAEV ASKER JUSUFOVICH, AZ'MUKO ANDREJ ANDREEVICH, MOLOKOEDOV ALEKSANDR SERGEEVICH, VILITKEVICH ELENA LEONIDOVNA, LAKOMKIN VLADIMIR LEONIDOVICH, SHIRINSKIJ VLADIMIR PAVLOVICH, SIDOROVA MARIJA VLADIMIROVNA, BUSHUEV VALERIJ NIKOLAEVICH, KAPEL'KO VALERIJ IGNAT'EVICH
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: biotechnologies.SUBSTANCE: peptide of the formula H-(N-Me)-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-D-Arg-Lys-NHis proposed. The proposed peptide may find application as an agent for reduction of pathological hyperpermeability of vessel endothelium in various areas of medicine (in cardiology, toxicology, neurosurgery, oncology, etc.).EFFECT: prevention of sharp increase of vessel endothelium permeability when injected to a recipient.3 cl, 4 dwg, 1 tbl, 5 ex Изобретение относится к биологически активным пептидам, способным предотвращать острое повышение проницаемости сосудистого эндотелия при введении реципиенту. Предложен пептид формулы H-(N-Me)-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-D-Arg-Lys-NH. Заявленный пептид может найти применение в качестве средства снижения патологической гиперпроницаемости сосудистого эндотелия в различных областях медицины (в кардиологии, токсикологии, нейрохирургии, онкологии и др.). 3 н.п. ф-лы, 4 ил., 1 табл., 5 пр.