IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR APPLICATION AS POSITIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS

FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel imidazo[1,2-a]pyridine derivatives of general formula(I) or to its stereochemical isomeric forms, or to its pharmaceutically acceptable salts, where Rrepresents Calkyl; Ccycloalkyl; trifluoromethyl; Calkyl, substituted with trifluoromethyl, Ccycloalkyl, phenyl; phenyl, substituted with 2 substituents, selected from group, consisting of halogeno; Rrepresents cyano, halogeno or Calkyl; Rrepresents radical of formula(a), or(b), or(d); Rrepresents hydroxyCcycloalkyl; pyridinyl, substituted with one Calkyl group; pyrimidinyl; pyrimidinyl, substituted with two Calkyl groups; phenyl; phenyl, substituted with 1 or 2 substituents, selected from group, consisting of halogeno, hydroxyCalkyl, mono- or polyhalogenoCalkyl, Calkyloxy and monohalogeno- Calkyloxy; Rrepresents hydrogen, fluoro, hydroxyl or monopholinyl; X represents C or N, with Rrepresenting electron pair on N; or R-X-Rrepresents radical of formula(i), or(j), or(k); n equals 0 or 1' q equals 1 or 2; Rrepresents Calkyl; Ccycloalkyl; hydroxyCalkyl; (Ccycloalkyl)Calkyl; phenyl; or phenyl, or pyridinyl, substituted with one substituent, selected from group, consisting of halogeno, Calkyl and (CH)-COH, where m equals 0; or Rrepresents cyclic radical of formula(l); where Rrepresents hydrogen, p equals 2; Z represents O or CR(OH), where Rrepresents hydrogen or Calkyl; Rrepresents hydrogen or halogeno; Y represents covalent bond, O, NH, S, C(OH)(CH), -CH-O-, -O-CH-, CHF or CF; or R-Y represents morpholinyl, pyrrolidinyl or piperidinyl, possibly substituted with hydroxyl or hydroxyCalkyl; and A represents O or NH. Invention also relates to pharmaceutical composition based on formula (I), its application and method of treatment or prevention of central nervous system disorders.EFFECT: novel imidazo[1,2-a]pyridine derivatives, which possess activity of positive allosteric mGluR2 modulator are obtained.21 cl, 3 tbl, 22 ex Настоящее изобретение относится к новым производным имидазо[1,2-а]пиридина общей формулы (I), или к его стереохимическим изомерным формам, или его фармацевтически приемлемым солям, где Rпредставляет собой Cалкил; Сциклоалкил; трифторметил; Салкил, замещенный трифторметилом, Сциклоалкилом, фенилом; фенил; фенил, замещенный 2 заместителями, выбранными из группы, состоящей из галогено; Rпредставляет собой циано, галогено или Cалкил; Rпредставляет собой радикал формулы (а), или (б), или (г); Rпредставляет собой гидроксиСциклоалк