5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composi...
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| creator | UEHJKFILD BRAJAN D AKRITOPOULOU-ZANZE IRINI MICHMERKHUZEN MELISSA DZH BAKKER MARGARETA LI BITSIN KOVAR PITER DZH MAK KHEL'MUT GRASIAS VIDZHAJA DZH LONG EHNDRJU DZH DZHORZH DON FRANK KRISTIN TOJSH NIKOL DZHONSON EHRIK F SARRIS KEHTI KHOBSON ADRIAN ST. DZHON MUR NAJDZHEL TERNER SHON K GASIKI ALAN F D'JURIK STIVEN V PATEL DZHIOTI R SHUAJ TSI VASUDEVAN ANIL VAN LU KALVIN DUGLAS M |
| description | FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composition containing the above compounds effective for inhibition of kinases, such as glycogen synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus kinase (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.EFFECT: preparing the specific compounds and pharmaceutical composition containing the above compounds effective for kinase inhibition.18 cl, 393 ex
Изобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, где A, RR, Rи m определены в формуле изобретения. Изобретение также относится к ряду конкретных соединений и фармацевтической композиции, содержащей указанные соединения, которые являются полезными для ингибирования киназ, таких как гликогенсинтаза-киназа 3 (GSK-3), Rho киназа (ROCK), Janus Киназы (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 и nek 2. 3 н. и 15 з.п. ф-лы, 393 пр. |
| format | Patent |
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Изобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, где A, RR, Rи m определены в формуле изобретения. Изобретение также относится к ряду конкретных соединений и фармацевтической композиции, содержащей указанные соединения, которые являются полезными для ингибирования киназ, таких как гликогенсинтаза-киназа 3 (GSK-3), Rho киназа (ROCK), Janus Киназы (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 и nek 2. 3 н. и 15 з.п. ф-лы, 393 пр.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130720&DB=EPODOC&CC=RU&NR=2487873C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130720&DB=EPODOC&CC=RU&NR=2487873C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UEHJKFILD BRAJAN D</creatorcontrib><creatorcontrib>AKRITOPOULOU-ZANZE IRINI</creatorcontrib><creatorcontrib>MICHMERKHUZEN MELISSA DZH</creatorcontrib><creatorcontrib>BAKKER MARGARETA</creatorcontrib><creatorcontrib>LI BITSIN</creatorcontrib><creatorcontrib>KOVAR PITER DZH</creatorcontrib><creatorcontrib>MAK KHEL'MUT</creatorcontrib><creatorcontrib>GRASIAS VIDZHAJA DZH</creatorcontrib><creatorcontrib>LONG EHNDRJU DZH</creatorcontrib><creatorcontrib>DZHORZH DON</creatorcontrib><creatorcontrib>FRANK KRISTIN</creatorcontrib><creatorcontrib>TOJSH NIKOL</creatorcontrib><creatorcontrib>DZHONSON EHRIK F</creatorcontrib><creatorcontrib>SARRIS KEHTI</creatorcontrib><creatorcontrib>KHOBSON ADRIAN</creatorcontrib><creatorcontrib>ST. DZHON MUR NAJDZHEL</creatorcontrib><creatorcontrib>TERNER SHON K</creatorcontrib><creatorcontrib>GASIKI ALAN F</creatorcontrib><creatorcontrib>D'JURIK STIVEN V</creatorcontrib><creatorcontrib>PATEL DZHIOTI R</creatorcontrib><creatorcontrib>SHUAJ TSI</creatorcontrib><creatorcontrib>VASUDEVAN ANIL</creatorcontrib><creatorcontrib>VAN LU</creatorcontrib><creatorcontrib>KALVIN DUGLAS M</creatorcontrib><title>5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS</title><description>FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composition containing the above compounds effective for inhibition of kinases, such as glycogen synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus kinase (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.EFFECT: preparing the specific compounds and pharmaceutical composition containing the above compounds effective for kinase inhibition.18 cl, 393 ex
Изобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, где A, RR, Rи m определены в формуле изобретения. Изобретение также относится к ряду конкретных соединений и фармацевтической композиции, содержащей указанные соединения, которые являются полезными для ингибирования киназ, таких как гликогенсинтаза-киназа 3 (GSK-3), Rho киназа (ROCK), Janus Киназы (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 и nek 2. 3 н. и 15 з.п. ф-лы, 393 пр.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNA21Q0OdQoO8QwJDXF1UfD0c3GM8vdxVXAMVvD29HMMdgUKeXg6eYb4BwXzMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4oFAjEwtzC3NjZyNjIpQAADl9JNQ</recordid><startdate>20130720</startdate><enddate>20130720</enddate><creator>UEHJKFILD BRAJAN D</creator><creator>AKRITOPOULOU-ZANZE IRINI</creator><creator>MICHMERKHUZEN MELISSA DZH</creator><creator>BAKKER MARGARETA</creator><creator>LI BITSIN</creator><creator>KOVAR PITER DZH</creator><creator>MAK KHEL'MUT</creator><creator>GRASIAS VIDZHAJA DZH</creator><creator>LONG EHNDRJU DZH</creator><creator>DZHORZH DON</creator><creator>FRANK KRISTIN</creator><creator>TOJSH NIKOL</creator><creator>DZHONSON EHRIK F</creator><creator>SARRIS KEHTI</creator><creator>KHOBSON ADRIAN</creator><creator>ST. 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DZHON MUR NAJDZHEL</au><au>TERNER SHON K</au><au>GASIKI ALAN F</au><au>D'JURIK STIVEN V</au><au>PATEL DZHIOTI R</au><au>SHUAJ TSI</au><au>VASUDEVAN ANIL</au><au>VAN LU</au><au>KALVIN DUGLAS M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS</title><date>2013-07-20</date><risdate>2013</risdate><abstract>FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composition containing the above compounds effective for inhibition of kinases, such as glycogen synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus kinase (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.EFFECT: preparing the specific compounds and pharmaceutical composition containing the above compounds effective for kinase inhibition.18 cl, 393 ex
Изобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, где A, RR, Rи m определены в формуле изобретения. Изобретение также относится к ряду конкретных соединений и фармацевтической композиции, содержащей указанные соединения, которые являются полезными для ингибирования киназ, таких как гликогенсинтаза-киназа 3 (GSK-3), Rho киназа (ROCK), Janus Киназы (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 и nek 2. 3 н. и 15 з.п. ф-лы, 393 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS |
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