5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS

5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composi...

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Hauptverfasser: UEHJKFILD BRAJAN D, AKRITOPOULOU-ZANZE IRINI, MICHMERKHUZEN MELISSA DZH, BAKKER MARGARETA, LI BITSIN, KOVAR PITER DZH, MAK KHEL'MUT, GRASIAS VIDZHAJA DZH, LONG EHNDRJU DZH, DZHORZH DON, FRANK KRISTIN, TOJSH NIKOL, DZHONSON EHRIK F, SARRIS KEHTI, KHOBSON ADRIAN, ST. DZHON MUR NAJDZHEL, TERNER SHON K, GASIKI ALAN F, D'JURIK STIVEN V, PATEL DZHIOTI R, SHUAJ TSI, VASUDEVAN ANIL, VAN LU, KALVIN DUGLAS M
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to compounds of formula (I)or pharmaceutically acceptable salts thereof wherein A, R, R, Rand m are specified in the patent claim. The present invention also refers to the number of specific compounds, and to a pharmaceutical composition containing the above compounds effective for inhibition of kinases, such as glycogen synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus kinase (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.EFFECT: preparing the specific compounds and pharmaceutical composition containing the above compounds effective for kinase inhibition.18 cl, 393 ex Изобретение относится к соединениям формулы (I) или их фармацевтически приемлемым солям, где A, RR, Rи m определены в формуле изобретения. Изобретение также относится к ряду конкретных соединений и фармацевтической композиции, содержащей указанные соединения, которые являются полезными для ингибирования киназ, таких как гликогенсинтаза-киназа 3 (GSK-3), Rho киназа (ROCK), Janus Киназы (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 и nek 2. 3 н. и 15 з.п. ф-лы, 393 пр.