HYDROXYLATED AND METHOXYLATED CYCLOPENTA[B]PYRIMIDINES AS PROTEIN KINASE INHIBITORS

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to new compounds of general formula(I), (the radical values are presented in the patent claim) including their split enantiomers, split diastereomers, solvates and pharmaceutically acceptable salts. What is also described is a method...

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Hauptverfasser:	KALLAN NIKOLAS K, SHLEKHTER STIVEN T, KSIAO DENGMING, KSU RUI, DO STIVEN, LIANG DZUN, MITCHELL JAN S, BENKSIK JOZEF R, SAFINA BRAJAN, BEHNKA ANNA L, SPENSER KIT LI, CHZHANG BIRONG, CHABOT KRISTIN, BLEHJK DZHEJMS F, UOLLES ILAJ M
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to new compounds of general formula(I), (the radical values are presented in the patent claim) including their split enantiomers, split diastereomers, solvates and pharmaceutically acceptable salts. What is also described is a method for preparing new compounds, a pharmaceutical composition containing them.EFFECT: use of the compounds as protein kinase inhibitors and a method of treating cancer.113 cl, 49 ex, 1 tbl Настоящее изобретение относится к новым соединениям общей формулы (I)(значения радикалов приведены в формуле изобретения) включая их разделенные энантиомеры, разделенные диастереомеры, сольваты и фармацевтически приемлемые соли. Описывается также способ получения новых соединений, фармацевтическая композиция их содержащая, применение соединений по настоящему изобретению в качестве ингибиторов АКТ протеинкиназы и способ лечения рака. 7 н. и 106 з.п. ф-лы, 49 пр., 1 табл.