DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASE

FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I:,where Xdenotes a bond, NRor S; Ydenotes O or NR ; Rdenotes Calkyl, Caryl or a 5-10-member heteroaryl containing 1-3 heteroatoms which are independently selected from N or S; where said Ris optionally substituted with 0-2 J; Rdenotes H or Calkyl; each of R, R, Rand Rindependently denotes H or Calkyl; and Rdenotes Calkyl, Ccycloalkyl, phenyl, 5-6-member heterocyclyl containing 1-3 heteroatoms independently selected from O and N, - (Calkyl) -(Ccycloalkyl), - (Calkyl) - (phenyl) or -(Calkyl)-(6-member heterocyclyl containing 2 heteroatoms selected from O and N); where said Ris optionally substituted with 0-5 J; or Rand R, together with a carbon atom with which they are bonded, optionally form a 3-4-member saturated or partially unsaturated monocyclic fragment; Rand R, together with carbon atoms with which they are bonded, optionally form a 5-member monocyclic fragment; Rdenotes H; Rdenotes H or unsubstituted Calkyl; or Rand R, together with atoms with which they are bonded, optionally form a 5-member aromatic monocyclic fragment containing 3 nitrogen atoms; each Jindependently denotes Chalogenalkyl, halogen, NO, CN, Q or -Z-Q; or two Jtogether can optionally form =O; Z denotes Calkyl, wherein 0-3 carbon atoms are optionally substituted with -NR-, -O-, -C(O)- or -SO-; wherein each Z is optionally substituted with 0-2 J; Q denotes H; Calkyl; 3-8-member aromatic or non-aromatic monocyclic fragment containing 0-3 heteroatoms independently selected from O, N and S; or an 8-10-member aromatic bicyclic system; each Q is optionally substituted with 0-2 J; each Jindependently denotes Calkyl or halogen(Calkyl); each of Jand Jindependently denotes M or -Y-M; each Y independently denotes an unsubstituted Calkyl, wherein 0-3 carbon atoms are optionally substituted with -O-, -C(O)- or -SO-; each M independently denotes H, Calkyl, C-cycloalkyl; halogen (Calkyl), phenyl, halogen, CN, OH, OR; or two M together can optionally form =O; R denotes H or an unsubstituted Calkyl; R' denotes an unsubstituted Calkyl. The invention also relates to methods of producing said compounds and a pharmaceutical composition for inhibiting PLK based on said compounds.EFFECT: novel compounds which can be used in medicine as inhibitors of protein kinase are obtained.34 cl, 1 tbl, 279 ex Изобретение относится к соединению формулы Iгде Хобозначает связь, NRили S; Yобозначает О или NR; Rобозначает Cалкил, Сарил или 5-10-членный