POLYCYCLIC INDAZOLE-DERIVATIVES AND THEIR APPLICATION AS ERK INHIBITORS FOR CANCER TREATMENT

FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to particular compounds, which demonstrate inhibiting activity with respect to ERK, whose structure formula is given in description, to their pharmaceutically acceptable salts, based on them pharmaceutical composition and their application...

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Hauptverfasser:	DESAI JAGDISH, PALIUOL SANIL, PATEL MEKHAL, SHIKH NENG-JANG, SHIPPS DZHERAL'D V. ML, TSUI KHONUNG, ALKHASSAN ABDUL-BASIT, ZHU KHUG, KELLI DZHOZEF, BOGA SOBKHANA BABU, ZHU LIANG, DOLL RONAL'D, VANG DZHEJMS, NAN JANG, DENG JONGKI, KUPER ALAN, GAO KSJAOLEJ
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to particular compounds, which demonstrate inhibiting activity with respect to ERK, whose structure formula is given in description, to their pharmaceutically acceptable salts, based on them pharmaceutical composition and their application for treatment of cancer, mediated by ERK activity.EFFECT: obtaining compounds, which demonstrate inhibiting activity with respect to ERK.5 cl Изобретение относится к конкретным соединениям, проявляющим ингибирующую активность в отношении ERK, структурная формула которых указана в описании, их фармацевтически приемлемым солям, фармацевтической композиции на их основе и их применению для лечения рака, опосредованного активностью ERK. 5 н.п. ф-лы.