METHOD FOR EXPERIMENTAL AZYTHROMYCIN CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER IN ADMA-LIKE GESTOSIS MODELS

METHOD FOR EXPERIMENTAL AZYTHROMYCIN CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER IN ADMA-LIKE GESTOSIS MODELS

FIELD: medicine. ^ SUBSTANCE: invention refers to medicine. A method involves a reproducible ADMA-like gestosis model in pregnant female rats Wistar by the daily 7-day intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. This daily 7-day intraperitoneal introduction is combined wi...

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Hauptverfasser: BELOUS ALEKSANDR SERGEEVICH, ALEKHINA VALERIJA VALER'EVNA, BRATCHIKOV OLEG IVANOVICH, TEREKHOVA ELENA GENNAD'EVNA, BABKO ANNA VLADIMIROVNA, GUDYREV OLEG SERGEEVICH, ARTJUSHKOVA ELENA BORISOVNA, PAKHOMOV SERGEJ PETROVICH, GOLOVCHENKO IL'JA OLEGOVICH, KHADIEVA TAISIJA ABDULADIROVNA, POKROVSKIJ MIKHAIL VLADIMIROVICH, TSYBUL'SKIJ IGOR' VALER'EVICH, ALEKHIN SERGEJ ALEKSANDROVICH, GUREEV VLADIMIR VLADIMIROVICH, POLJANSKAJA OKSANA SERGEEVNA, KOTEL'NIKOVA LILIJA VIKTOROVNA, KOROKIN MIKHAIL VIKTOROVICH, MOSTOVOJ ALEKSANDR SERGEEVICH, FILIMONOV VJACHESLAV ALEKSANDROVICH, ZHERNAKOV EVGENIJ VLADISLAVOVICH, CHERNOMORTSEVA ELENA STANISLAVOVNA
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Sprache:eng ; rus
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MEDICAL OR VETERINARY SCIENCE
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Zusammenfassung:FIELD: medicine. ^ SUBSTANCE: invention refers to medicine. A method involves a reproducible ADMA-like gestosis model in pregnant female rats Wistar by the daily 7-day intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. This daily 7-day intraperitoneal introduction is combined with the intragastric introduction of the antibacterial preparation Azythromycin 30 mg/kg/day of the group of macrolides. ^ EFFECT: method is effective for correction of placental microcirculation disorder. ^ 1 ex Изобретение относится к области медицины. Способ включает включающий воспроизведение ADMA-подобной модели гестоза у беременных крыс самок линии Wistar ежедневным в течение 7 сут внутрибрюшинным введением L-нитро-аргинин-метилового эфира в дозе 25 мг/кг. На фоне этого ежедневно в течение 7 суток крысам вводят внутрижелудочно антибактериальный препарат из группы макролидов «Азитромицин» в дозе 30 мг/кг/сут. Способ эффективен для коррекции нарушения микроциркуляции в плаценте. 1 пр.