(E)-4'-ARYL-7'-ARYLMETHYLENE-4',5',6',7'-TETRAHYDRO-2'H-SPIRO[CYCLOALKANE-1,3'-CYCLOPENTA[b]PYRAN]-2'-ONES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF

FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing (E)-4'-aryl-7'-arylmethylene-4',5',6',7'-tetrahydro-2'H-spiro[cycloalkane-1,3'-cyclopenta[b]pyran]-2'-ones of general formula (I) n=1, 2, 3. The method is realised by boiling methyl...

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Hauptverfasser:	KIRILLOV NIKOLAJ FEDOROVICH, MAKHMUDOV RAMIZ RAGIBOVICH, GAVRILOV ALEKSANDR GENNAD'EVICH, MARDANOVA LJUDMILA GENNAD'EVNA
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

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Zusammenfassung:	FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing (E)-4'-aryl-7'-arylmethylene-4',5',6',7'-tetrahydro-2'H-spiro[cycloalkane-1,3'-cyclopenta[b]pyran]-2'-ones of general formula (I) n=1, 2, 3. The method is realised by boiling methyl esters of 1-bromocyclohexane carboxylic acids with zinc and 2,5-bis-arylmethylenepentanones in a benzene - ethylacetate - HMPA medium (10:5:1) for 4 hours. ^ EFFECT: method of producing novel compounds of formula (I), exhibiting analgesic activity. ^ 4 ex, 1 tbl Изобретение относится к способу получения (Е)-4'-арил-7'-арилметилен-4',5',6',7'-тетрагидро-2'Н-спиро[циклоалкан-1,3'-циклопента[b]пиран]-2'-онам общей формулы (I). Способ осуществляют путем кипячения метиловых эфиров 1-бромциклогексанкарбоновых кислот с цинком и 2,5-бис-арилметиленпентанонами в среде бензол-этилацетат - ГМФТА (10:5:1) в течение 4 часов. Технический результат - способ получения новых соединений формулы (I), проявляющих анальгетическую активность. 4 пр., 1 табл. !! n=1, 2, 3.