SYNTHESIS OF CHIRALLY PURE SUBSTITUTED BENZOTHIAZOLE DIAMINES

SYNTHESIS OF CHIRALLY PURE SUBSTITUTED BENZOTHIAZOLE DIAMINES

FIELD: chemistry. ^ SUBSTANCE: invention discloses methods of producing chirally pure substituted 4,5,6,7-tetrahydrobenzothiazole diamines such as, for example, (6R)-2-amino-4.5,6,7-tetrahydro-6-(propylamino)benzothiazole, and salts thereof, as well as purification of the predominant enantiomer of s...

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Hauptverfasser: LAPINA OL'GA, CHEHN' TSZJAN'-SE, MAKKOLL DZHON M, GADIKOTA RADZHENDRAKUMAR REDDI, RADZHE PRASAD
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:FIELD: chemistry. ^ SUBSTANCE: invention discloses methods of producing chirally pure substituted 4,5,6,7-tetrahydrobenzothiazole diamines such as, for example, (6R)-2-amino-4.5,6,7-tetrahydro-6-(propylamino)benzothiazole, and salts thereof, as well as purification of the predominant enantiomer of substituted 4,5,6,7-tetrahydrobenzothiazole diamines from enantiomer-rich mixtures of substituted 4,5,6,7-tetrahydrobenzothiazole diamines. ^ EFFECT: improved method of producing chirally pure substituted 4,5,6,7-tetrahydrobenzothiazole diamines. ^ 23 cl, 25 ex, 6 tbl, 7 dwg В изобретении представлены способы получения хирально очищенных замещенных 4,5,6,7-тетрагидробензотиазолдиаминов, таких как, например, (6R)-2-амино-4.5,6,7-тетрагидро-6-(пропиламино)бензотиазол, и их солей, а также очистка преобладающего энантиомера замещенных 4,5,6,7-тетрагидробензотиазолдиаминов из энантиомерно обогащенных смесей замещенных 4,5,6,7-тетрагидробензотиазолдиаминов. 2 н. и 21 з.п. ф-лы, 6 табл., 7 ил., 25 пр.