NEW COMPOUNDS ACTING AS ERK INACTIVATORS

NEW COMPOUNDS ACTING AS ERK INACTIVATORS

FIELD: chemistry. ^ SUBSTANCE: invention refers to new indazole derivants with the formula (1.0) or to their pharmaceutically acceptable salts and isomerides that act as inactivators in relation to ERK2. In formula (1.0): meanings of the chemical groups Q, R1, R2 are given in the invention formula....

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Hauptverfasser: DESAI JAGDISH, KSIAO LI, SHIKH NENG-JANG, ZHU KH'JU, KHRUZA ALAN, SAN ROBERT, SHIPPS DZHERAL'D V. ML, DONG JUKHAO, MEHDISON VINSENT S, SAMATAR AKHMED, TSUI KHONUNG, CHELEBI AZIM A, KELLI DZHOZEF, BOGA SOBKHANA BABU, VU JIDZHI, DOLL RONAL'D, VANG TONG, VANG DZHEJMS, NAN JANG, DENG JONGKI, PALIVAL SUNIL, KUPER ALAN, SIDDIKI M. ARSHAD
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:FIELD: chemistry. ^ SUBSTANCE: invention refers to new indazole derivants with the formula (1.0) or to their pharmaceutically acceptable salts and isomerides that act as inactivators in relation to ERK2. In formula (1.0): meanings of the chemical groups Q, R1, R2 are given in the invention formula. The invention also refers to the pharmaceutical composition containing the mentioned compounds and to application of the compounds with the formula (1.0) for production of crude drugs used in malignant growth treatment. ^ EFFECT: application of the compounds for production of crude drugs used in malignant growth treatment. ^ 65 cl, 611 ex, 27 tbl Изобретение относится к новым производным индазола формулы (1.0) или их фармацевтически приемлемым солям и изомерам, которые обладают ингибирующей активностью в отношении ЕКК2. В формуле (1.0): ! ! значения радикалов Q, R1, R2 приведены в формуле изобретения. Изобретение также относится к фармацевтической композиции, содержащей указанные соединения, и к применению соединений формулы (1.0) для производства лекарственного средства для лечения злокачественной опухоли. 3 н. и 62 з.п. ф-лы, 27 табл.