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FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of biotechnology. Claimed is composition of buffer of pharmaceutical composition which contains pertuzumab. Hystidine-acetate- based buffer which has pH level from 5.5 to 6.5. ^ EFFECT: reduction of deamination and aggregation o...

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Hauptverfasser:	EHND'JA DZHEJMS D, GVI SHIAN K, LJU TSZJUN, SHEHN' E
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Zusammenfassung:	FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of biotechnology. Claimed is composition of buffer of pharmaceutical composition which contains pertuzumab. Hystidine-acetate- based buffer which has pH level from 5.5 to 6.5. ^ EFFECT: reduction of deamination and aggregation of pertuzumab in process of long-term storage. ^ 44 cl, 12 ex, 9 tbl, 33 dwg Изобретение относится к области биотехнологии. Предложен состав буфера фармацевтической композиции, содержащей пертузумаб. Буфер на основе гистидин-ацетата, имеющий уровень рН от 5,5 до 6,5, обеспечивает снижение дезаминирования и агрегации пертузумаба в процессе длительного хранения. 4 н. и 40 з.п. ф-лы, 9 табл, 33 ил.