METHOD OF PREDICTING DISEASE COURSE IN CHILDREN IN CASE OF ACUTE RESPIRATORY VIRAL INFECTIONS

FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely, to immunology and clinic laboratory diagnostics, and can be used to predict course of acute respiratory viral infections (ARVI) in children in the first days of disease and timely administration of immunomodulating medications. For this purpose by means of ELISA immunologic indices of spontaneous and induced interferon- in vitro (IFH-) are determined. Index of interferon- stimulation (IS IFH-) is calculated by division of index of induced level by index of spontaneous level of interferon-. Also carried out is calculation of lymphocyte activation index (LAI IFH-) per 1000 lymphocytes by division of index of induced interferon- by absolute number of patient's lymphocytes. Additionally in blood plasma determined is content of interleukin-10 (IL-10). If values of IS IFH- are higher than 3, LAI IFH- equals or is higher than 40, IL-10 is from 30 to 60 pg/ml favourable outcome of disease is predicted with therapeutic treatment which does not include immunomodulators. If IS IFH- is lower than 3, LAI IFH- is lower than 40, IL-10 is from 60 to 100 pg/ml, predicted are severe course of disease and development of complications, which requires urgent treatment by immunomodelling therapy. If IS IFH- is lower than 3, LAI IFH- is lower than 30, IL-10 is higher than 100 pg/ml, predicted are severe course of disease with development of bronchopulmonary complications and possible chronisation of pathologic process and recurrent ARVD, which requires additional introduction of immunomodelling medications. ^ EFFECT: increase of accuracy of early prediction of disease course severity and development of complications in children with ARVI, including those from 1 month old, which makes it possible to carry out necessary anti-viral and immunomodelling therapy, aimed at strengthening immunity cell responses, in due time. ^ 3 tbl, 3 ex Изобретение относится к медицине, а именно к иммунологии и клинической лабораторной диагностике, и может быть использовано для прогнозирования течения острых респираторных вирусных инфекций (ОРВИ) у детей в первые дни заболевания и своевременного назначения иммуномодулирующих препаратов. Для этого методом иммуноферментного анализа определяют иммунологические показатели спонтанного и индуцированного интерферона-γ in vitro (ИФН-γ). Проводят расчет индекса стимуляции интерферона-γ (ИС ИФН-γ) путем деления показателя индуцированного уровня на показатель спонтанного уровня интерферона-γ. П