METHOD OF PRODUCING RIBOFURANOSYL-PYRIMIDINE NUCLEOSIDES

METHOD OF PRODUCING RIBOFURANOSYL-PYRIMIDINE NUCLEOSIDES

FIELD: chemistry. ^ SUBSTANCE: method enables to obtain 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one of formula (IV), which is a strong inhibitor of NS5B polymerase of hepatitis C virus (HCV). ^ EFFECT: high yield. ^ 2 cl, 4 ex Настоя...

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Hauptverfasser: SARMA KESHAB, RACHAKONDA SUGUNA, CHUN B'EN-KVON, CHZHU TSZJAN, VAJTEHJL DZHASTIN, ROSS BRJUS, TSZIN' TSINVU, EHKST STIVEN D
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:FIELD: chemistry. ^ SUBSTANCE: method enables to obtain 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one of formula (IV), which is a strong inhibitor of NS5B polymerase of hepatitis C virus (HCV). ^ EFFECT: high yield. ^ 2 cl, 4 ex Настоящий способ обеспечивает получение 4-амино-1-((2R,3R,4R,5R)-3-фтор-4-гидрокси-5-гидроксиметил-3-метил-тетрагидро-фуран-2-ил)-1H-пиримидин-2-она формулы (IV), который является сильным ингибитором NS5B полимеразы вируса гепатита С (HCV). 1 з.п. ф-лы.