NOVEL CRYSTALLINE FORMS OF PYRROLYL HEPTANOIC ACID DERIVATIVES

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel crystalline forms D1 and D2 of R-(R*,R*)]-2-(4-fluorophenyl)-, -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, semi-calcium salt, hydrates thereof, which have high stability. ^ EFFECT: improved met...

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Hauptverfasser:	CHA DAE VON, KIM JONG DZIK, CHOJ DZUN KHO, JOO MOO KHI, PARK SEONG DZIN, KIM MOON SUNG, SUNG SI JANG, RKHEE DZAE KEOL, LIM KHONG GIU
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: chemistry. ^ SUBSTANCE: invention relates to novel crystalline forms D1 and D2 of R-(R,R)]-2-(4-fluorophenyl)-, -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, semi-calcium salt, hydrates thereof, which have high stability. ^ EFFECT: improved methods of producing novel crystalline forms. ^ 15 cl, 4 dwg, 6 tbl, 4 ex Изобретение относится к новым кристаллическим формам D1 и D2 [R-(R,R)]-2-(4-фторфенил)-β,δ-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1Н-пиррол-1-гептановой кислоты, полукальциевой соли, их гидратам, которые обладают повышенной стабильностью. Описаны способы получения новых кристаллических форм. 7 н. и 8 з.п. ф-лы, 4 ил., 6 табл.