HYDROHALOGENIDES 3-[1-(2-HYDROXY-3-PIPERIDINE-1-YL-PROPYL)-1H-INDOLE-3-YL]-1-PHENYL-PROPENONE, HAVING LOCAL ANAESTHETISING AND ANTI-ARRHYTHMIC ACTIVITY

HYDROHALOGENIDES 3-[1-(2-HYDROXY-3-PIPERIDINE-1-YL-PROPYL)-1H-INDOLE-3-YL]-1-PHENYL-PROPENONE, HAVING LOCAL ANAESTHETISING AND ANTI-ARRHYTHMIC ACTIVITY

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to new derivatives of 3-(2-carbonylvinyl)indole, namely to hydrohalogenides 3-[1-(2-hydroxy-3-piperidine-1-yl-propyl)-1H-indole-3-yl]-1-phenyl-propenone of formula I: , where R = H, Br, alkyl C1-C6, X = CI, Br, having local anaesthetisin...

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Hauptverfasser: GALENKO-JAROSHEVSKIJ PAVEL ALEKSANDROVICH, TARAN OKSANA ANATOL'EVNA, VARLASHKINA INESSA ALEKSANDROVNA, BGUASHEVA BEHLLA ASKEROVNA, SUZDALEV KONSTANTIN FILIPPOVICH, TAKHCHIDI KHRISTO PERIKLOVICH, DOL'SKAJA OKSANA ALEKSANDROVNA, LISITSYNA NADEZHDA PAVLOVNA, BOGUS SAIDA KAZBEKOVNA, SHEJKH-ZADE JURIJ RESHADOVICH, CHEREDNIK IRINA LEONIDOVNA, DEN'KINA SOF'JA VLADIMIROVNA, SAKHNOV SERGEJ NIKOLAEVICH
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to new derivatives of 3-(2-carbonylvinyl)indole, namely to hydrohalogenides 3-[1-(2-hydroxy-3-piperidine-1-yl-propyl)-1H-indole-3-yl]-1-phenyl-propenone of formula I: , where R = H, Br, alkyl C1-C6, X = CI, Br, having local anaesthetising (surface, infiltration, conductor and epidural) and anti-arrythmic (anti-fibrillatory) activity. ^ EFFECT: production of new compounds, having local anaesthetising activity. ^ 1 cl, 12 tbl, 1 ex Изобретение относится к новым производным 3-(2-карбонилвинил)индола, а именно к гидрогалогенидам 3-[1-(2-гидрокси-3-пиперидин-1-ил-пропил)-1Н-индол-3-ил]-1-фенилпропенона формулы I: ! где R=Н, Br, алкил C1-С6, Х=Cl, Br, обладающим местноанестезирующей (поверхностной, инфильтрационной, проводниковой и эпидуральной) и антиаритмической (противофибрилляторной) активностью. 12 табл.